Respiratory delivery of passive immunotherapies for SARS-CoV-2 prophylaxis and therapy

Focosi, Daniele; Maggi, Fabrizio

doi:10.1080/21645515.2023.2260040

Cited by 2 publications

(1 citation statement)

References 59 publications

(63 reference statements)

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“…Finally, delivery of CCP into the respiratory mucosae of the upper respiratory tract, which represents the entry door for SARS-CoV-2, is worth investigating in early outpatients, granting higher safety and lower therapeutic doses [37].…”

Section: Greys Zonesmentioning

confidence: 99%

The Role of Convalescent Plasma in COVID-19: A Conclusive Post-Pandemic Review

Franchini,

Focosi

2023

Life

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COVID-19 convalescent plasma (CCP) has represented the frontline response to the COVID-19 pandemic, largely because of encouraging historical evidences in previous pandemics, biological plausibility, and the initial unavailability of targeted antivirals. Unfortunately, investigator-initiated randomized clinical trials in 2020, launched during a stressful pandemic peak, were designed mostly at addressing the main unmet need, i.e., treating critically ill hospitalized patients who were unlikely to benefit from any antiviral therapy. The failure of most of these drugs, in combination with the lack of any sponsor, led to the false belief that convalescent plasma was useless. With the relaxing pandemic stages, evidences have instead mounted that, when administered properly (i.e., within 5 days from onset of symptoms and at high titers of neutralizing antibodies), CCP is as effective as other antivirals at preventing disease progression in outpatients, and also reduces mortality in hospitalized patients. Recently, the focus of clinical use has been on immunosuppressed patients with persistent seronegativity and infection, where a randomized clinical trial has shown a reduction in mortality. Lessons learnt during the COVID-19 pandemic will be of utmost importance for future pandemics.

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Section: Greys Zonesmentioning

confidence: 99%