Respiratory cancer in a cohort of nickel sinter plant workers.

Chovil, Alan; Sutherland, Roanne; Halliday, Mabel L.

doi:10.1136/oem.38.4.327

Cited by 22 publications

(23 citation statements)

References 7 publications

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“…Ciccarelli et al (65) observed increased DNA strandbreaks and crosslinks in kidney nuclei from nickel carbonate-treated rats at doses of 15 or 20 mg/kg (ip), but no significant DNA damage was found in rats receiving 10-mg/kg nickel carbonate injection. Robison et al (67) confirmed the results in cultured CHO cells exposed to nickel chloride (1 p-l01Lg/mL) and crystalline nickel sulfide (1,5,20 14g/mL).…”

Section: Dna Strand Breaks and Crosslinksmentioning

confidence: 76%

“…Because epidemiological investigation is a primary and potential tool to evaluate the risk of nickel-induced occupational lung cancer, numerous epidemiological studies have been carried out since the first recognition of high lung cancer risk in workers from a nickel refinery in Wales (3)(4)(5)(6)(7)(8)(9). Most of them were historical perspective studies and the high lung cancer risk was observed, especially in nickel refinery (4,7,8,9).…”

Section: Epidemiological Investigationsmentioning

confidence: 99%

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Risk assessment of nickel carcinogenicity and occupational lung cancer.

Shen

Zhang

1994

Environ Health Perspect

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Recent progress in risk assessment of nickel carcinogenicity and its correlation with occupational lung cancer in nickelexposed workers is reviewed. Epidemiological investigations provide reliable data indicating the close relation between nickel exposure and high lung cancer risk, especially in nickel refieries. The nickel species-specific effects and the doseresponse relationship between nickel exposure and lung cancer are among the main questions that are explored extensively. It is also suggested that some confounding factors such as cigarette smoking cannot be neglected. The determination of nickel concentration in lung tissue may be conducive to estimating the nickel exposure level, but it is uncertain whether the high nickel content in lung tissue indicates high lung cancer risk in nickel-exposed workers. Immunologic studies suggest that the suppressive effect ofnickel on NK cell activity and interferon production may also be involved in the mechanisms of nickel carcinogenesis. As a potential mutagen, nickel can cause chromosome damage both in vitro and in vivo; and on a molecular basis, nickel is found to induce DNA damage (DNA strandbreaks and crosslinks, infidelity of DNA replication, inhibition ofDNA repair, and the helical transition ofB-DNA toZ-DNA) by binding ofnickel ions to DNA and nuclear proteins. The discovery of oncogene promises both a challenge and an opportunity for nickel carcinogenesis research. It can be predicted that, with the rapid development ofmolecular biology and oncology, new approaches will be established for both understanding and controlling nickel-induced occupational lung cancer.

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Section: Dna Strand Breaks and Crosslinksmentioning

confidence: 76%

Section: Epidemiological Investigationsmentioning

confidence: 99%

Risk assessment of nickel carcinogenicity and occupational lung cancer.

Shen

Zhang

1994

Environ Health Perspect

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“…Data from the Workmen's Compensation Board of Ontario (WCBO) reported 36 cases and deaths of nasal cancer (combined) between 1947 and 1979 from PCNR (49). Interestingly, the eight extra observation years (1977)(1978)(1979)(1980)(1981)(1982)(1983)(1984) for the second update of the extended PCNR cohort produced only one additional nasal cancer death (table 2) (13,29).…”

Section: Changes In Cohort Definitionsmentioning

confidence: 99%

Unrecognized risks of nickel-related respiratory cancer among Canadian electrolysis workers

Grimsrud¹,

Andersen²

2012

Scand J Work Environ Health

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“…9 In addition, an increased inci-(Specimen 3) was found to have undergone prior exdence of paranasal sinus carcinoma has been found ternal beam radiotherapy for the treatment of SCC. in nickel foundry workers, 10 furniture and leather Sample accrual was limited due to the rarity of this workers, [11][12][13] and in chronic snuff users. 14 However, tumor and due to uncertainties as to the exact patholseveral investigators have shown that the major risk ogies of many of the reviewed tumor samples.…”

Section: Methodsmentioning

confidence: 99%

p53 alteration and human papilloma virus infection in paranasal sinus cancer

Caruana

Zwiebel

Cocker

et al. 1997

Cancer

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These data suggest that p53 alterations and/or HPV infection are associated predominantly with IPs exhibiting evidence of dysplasia or IPs associated with SCC, but not in nondysplastic, benign IPs. In addition, an inverse correlation may exist between oncogenic HPV infection and p53 alterations in paranasal sinus tumors. The authors postulate that patients with IPs containing altered p53 may be at increased risk for SCC of the paranasal sinus.

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Respiratory cancer in a cohort of nickel sinter plant workers.

Cited by 22 publications

References 7 publications

Risk assessment of nickel carcinogenicity and occupational lung cancer.

Risk assessment of nickel carcinogenicity and occupational lung cancer.

Unrecognized risks of nickel-related respiratory cancer among Canadian electrolysis workers

p53 alteration and human papilloma virus infection in paranasal sinus cancer

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