Respiratory Burst and Tyrosine Phosphorylation by Vanadate

Yamaguchi, M.; Oishi, Hiroko; Araki, Shiho; Saeki, Seitaro; Yamane, Haruki; Okamura, Nobuyuki; Ishibashi, Shun

doi:10.1006/abbi.1995.0058

Cited by 15 publications

(9 citation statements)

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“…Moreover, the relative phosphate acceptor potentials of c-Cbl tyrosine phosphorylation sites appear to rank in the same order for both anti-CD3 and pervanadate stimulation of Jurkat cells. These findings are consistent with the fact that pervanadate mimics natural stimuli with respect to both early signal transduction events and biological responses in T cells (51,53,54) as well as in other cell types (55)(56)(57)(58)(59).…”

Section: Discussionsupporting

confidence: 86%

Fyn, Yes, and Syk Phosphorylation Sites in c-Cbl Map to the Same Tyrosine Residues That Become Phosphorylated in Activated T Cells

Feshchenko

Langdon

Tsygankov

1998

Journal of Biological Chemistry

150

178

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Section: Discussionsupporting

confidence: 86%

Fyn, Yes, and Syk Phosphorylation Sites in c-Cbl Map to the Same Tyrosine Residues That Become Phosphorylated in Activated T Cells

Feshchenko

Langdon

Tsygankov

1998

Journal of Biological Chemistry

150

178

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“…Reactive oxygen species including H 2 O 2 are known to induce tyrosine phosphorylation in multiple cell types (13)(14)(15)(16)(17)(18)(19)(20). At moderate concentrations, they may influence gene expression as well as posttranscriptional modification of proteins.…”

Section: Discussionmentioning

confidence: 99%

“…This paradoxical situation suggests that in contrast to neutrophils, which generate large amounts of O 2 Ϫ and derived oxidants to kill bacteria during phagocytosis, B lymphocytes make use of their slowly generated O 2 Ϫ and its direct product of dismutation H 2 O 2 for other purposes, one of which might be to act as second messenger in signal transduction pathways (11,12). Our attention was recently drawn to reports mentioning that tyrosine-phosphorylation in a number of proteins in various cell types including myeloid HL60 cells, neutrophils, T and B lymphocytes is linked to the production of reactive oxygen species either generated endogenously by activated NADPH oxidase or added to the cells (13)(14)(15)(16)(17)(18)(19)(20). A feed-back regulation of NADPH oxidase activity through regulation of tyrosine kinase activity by H 2 O 2 was suggested (18, see Ref.…”

mentioning

confidence: 99%

Oxidant-Dependent Phosphorylation of p40phox in B Lymphocytes

Grandvaux

Elsen

Vignais

2001

Biochemical and Biophysical Research Communications

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“…It is well established that tyrosine phosphorylation plays a role in respiratory burst induction (Yamaguchi et al, 1995). Therefore, it is not surprising that YopH down- Fig.…”

Section: Yophmentioning

confidence: 96%

“…1) (Black and Bliska, 1997;Persson et al, 1997;Black et al, 1998;Hamid et al, 1999). YopH bears a similar three-dimensional structure to the mammalian PTPases (Stuckey et al, 1994), suggesting that YopH most probably catalyses tyrosine phosphate hydrolysis via a similar mechanism to the mammalian PTPases.It is well established that tyrosine phosphorylation plays a role in respiratory burst induction (Yamaguchi et al, 1995). Therefore, it is not surprising that YopH down- Yersinia are translocated into the host cell via a type III secretion system.…”

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confidence: 99%

Yersinia effectors target mammalian signalling pathways

2002

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SummaryAnimals have an immune system to fight off challenges from both viruses and bacteria. The first line of defence is innate immunity, which is composed of cells that engulf pathogens as well as cells that release potent signalling molecules to activate an inflammatory response and the adaptive immune system. Pathogenic bacteria have evolved a set of weapons, or effectors, to ensure survival in the host. Yersinia spp. use a type III secretion system to translocate these effector proteins, called Yops, into the host. This report outlines how Yops thwart the signalling machinery of the host immune system. Introduction Innate immunity and signallingInnate immunity is the first line of defence against bacterial and viral infection (for a review of innate immunity, see Medzhitov and Janeway, 2000). The cells involved in the immune response use a wide variety of signalling cascades to activate processes such as phagocytosis, cytokine production and release and production of reactive oxygen species. In addition to eliminating pathogens, the innate immune system activates the adaptive immune response through the presentation of foreign peptides to T cells.Phagocytosis is an essential component of the innate immune system (May and Machesky, 2001). Rearrangement of the actin cytoskeleton during phagocytosis is mediated by the recruitment of proteins that function in actin rearrangement; these include paxillin, p130Cas and focal adhesion kinase (FAK) (Greenberg et al., 1990;Allen and Aderem, 1996). These proteins may form through M cells (microfold cells), which are specialized cells that take up foreign antigens, in intestinal Peyer's patches (Autenrieth and Firsching, 1996). Recognition of Yersinia by M cells is mediated via b1 integrins on the M-cell plasma membrane and the invasin protein of Yersinia (Marra and Isberg, 1997;Clark et al., 1998). Once Yersinia has penetrated the M cells, it can localize in the lymphoid tissue of its host.The recently sequenced genome of Y. pestis (Parkhill et al., 2001) suggests that many of the genes that Yersinia uses during infection and invasion, including adhesins, secretion systems and insecticidal toxins, have been acquired from other bacteria and viruses. Furthermore, all three pathogenic species of Yersinia harbour an extrachromosomal plasmid of 70 kb that is essential for virulence (Portnoy and Martinez, 1985). This plasmid contains the genes of a type III secretion system, a translocation apparatus highly conserved among pathogenic Gram-negative bacteria (for a review, see Cornelis, 1998). This secretion system is responsible for the translocation of the Yersinia effectors, termed Yops, into the host cell. Once inside the host cell, Yops carry out disruption of signalling cascades that activate the processes of phagocytosis, cytokine release and respiratory burst. Six Yop effectors have been identified (YopH, YopE, YopJ/P, YpkA/YopO, YopT and YopM). Some of these effectors are known to function in the downregulation of critical signalling cascades of the immune system (Fig...

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Respiratory Burst and Tyrosine Phosphorylation by Vanadate

Cited by 15 publications

References 0 publications

Fyn, Yes, and Syk Phosphorylation Sites in c-Cbl Map to the Same Tyrosine Residues That Become Phosphorylated in Activated T Cells

Fyn, Yes, and Syk Phosphorylation Sites in c-Cbl Map to the Same Tyrosine Residues That Become Phosphorylated in Activated T Cells

Oxidant-Dependent Phosphorylation of p40phox in B Lymphocytes

Yersinia effectors target mammalian signalling pathways

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