Respiratory and Skeletal Muscles in Hypogonadal Men with Chronic Obstructive Pulmonary Disease

Laghi, Franco; Langbein, W. Edwin; Antonescu-Turcu, Andreea; Jubran, Amal; Bammert, Christine; Tobin, Martin J.

doi:10.1164/rccm.200412-1643oc

Cited by 42 publications

(47 citation statements)

References 65 publications

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“…2). When performing a progressive inspiratory threshold loading protocol, hypogonadal and eugonadal patients had similar respiratory muscle endurance times, perceived inspiratory effort and perceived air hunger [108]. Neither group of patients developed diaphragmatic fatigue after loading ( fig.…”

Section: Respiratory Musclesmentioning

confidence: 96%

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Endocrinological derangements in COPD

Laghi

Adıgüzel²,

Tobin³

2009

European Respiratory Journal

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Chronic obstructive pulmonary disease (COPD) is no longer considered to affect only the lungs and airways but also the rest of the body. The systemic manifestations of COPD include a number of endocrine disorders, such as those involving the pituitary, the thyroid, the gonads, the adrenals and the pancreas.The mechanisms by which COPD alters endocrine function are incompletely understood but likely involve hypoxaemia, hypercapnia, systemic inflammation and glucocorticoid administration. Altered endocrine function can worsen the clinical manifestations of COPD through several mechanisms, including decreased protein anabolism, increased protein catabolism, nonenzymatic glycosylation and activation of the rennin-angiotensin-aldosterone system.Systemic effects of endocrine disorders include abnormalities in control of breathing, decreases in respiratory and limb-muscle mass and function, worsening of respiratory mechanics, impairment of cardiac function and disorders of fluid balance.Research on endocrine manifestations of COPD embraces techniques of molecular biology, integrative physiology and controlled clinical trials. A sound understanding of the various disorders of endocrine function associated with COPD is prudent for every physician who practices pulmonary medicine.

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Section: Respiratory Musclesmentioning

confidence: 96%

“…Recently, LAGHI et al [108] reported that diaphragmatic contractility was similar in hypogonadal and eugonadal men with COPD ( fig. 2).…”

Section: Respiratory Musclesmentioning

confidence: 99%

Endocrinological derangements in COPD

Laghi

Adıgüzel²,

Tobin³

2009

European Respiratory Journal

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“…Low testosterone levels have been observed in patients with COPD (365)(366)(367)(368)(369) (368). In contrast, Van Vliet and colleagues observed that quadriceps strength, but not wholebody exercise tolerance, was related to low circulating testosterone levels (365).…”

Section: Mechanisms Of Limb Muscle Dysfunction In Copdmentioning

confidence: 99%

An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

Maltais¹,

Decramer²,

Casaburi³

et al. 2014

Am J Respir Crit Care Med

871

1,033

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“…Attempts at reversing muscle atrophy in cardiac failure and chronic obstructive airways disease using anabolic therapies have confirmed the presence of hypogonadism, but no significant correlation with respiratory capacity (Laghi et al 2005). In contrast, using a crossover design, short-term testosterone administration improved subjective and objective measures of exercise tolerance and metabolic factors in ten men with angina (Malkin et al 2004).…”

Section: Muscle Atrophy In Disuse Denervation and Medical Disordersmentioning

confidence: 99%

Modifying muscle mass – the endocrine perspective

Solomon

Bouloux

2006

Journal of Endocrinology

142

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This review describes the major hormonal factors that determine the balance between human skeletal muscle anabolism and catabolism in health and disease, with specific reference to age-related muscle loss (sarcopenia). The molecular mechanisms associated with muscle hypertrophy are described, and the central role of the satellite cell highlighted. The biological dynamics of satellite cells, varying between states of quiescence, proliferation and differentiation are strongly influenced by local endocrine factors. The molecular mechanisms of muscle atrophy are examined focussing on the causes of sarcopenia and associations with systemic medical disorders. In addition, evidence is provided that the mechanisms of atrophy and hypertrophy are unlikely to be simple opposites. Novel endocrine mechanisms underpinning mechanotransduction include IGF-I subtypes that may differentiate between endocrine and mechanical signals; their interaction with classical endocrine factors is an active area of translational research. Recently acquired knowledge on the mechanism of anabolic effects of androgens is also reviewed. The increasingly recognised role of myostatin, a negative regulator of muscle function, is described, as well as its potential as a therapeutic target. Strategies to counter age-related sarcopenia thus represent an exciting field of future investigation.

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Respiratory and Skeletal Muscles in Hypogonadal Men with Chronic Obstructive Pulmonary Disease

Cited by 42 publications

References 65 publications

Endocrinological derangements in COPD

Endocrinological derangements in COPD

An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

Modifying muscle mass – the endocrine perspective

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