Respiratory and non‐respiratory lung function indices during the development and resolution of O,S,S‐trimethyl phosphorodithioate‐induced lung damage in the rat. A chemical model of adult respiratory distress syndrome
Abstract:Arterial blood gases and the pulmonary uptake of putrescine and 5-hydroxytryptamine (5-HT) were studied between 6 h and 18 days after the administration to rats of an oral LD50-dose of the pneumotoxin, O,S,S-trimethyl phophorodithioate (OSSMe), a potential impurity in several organophosphorus insecticides. Aortic blood was sampled under pentobarbitone anaesthesia for measurements of arterial pH, and partial pressures of oxygen (PaO2) and carbon dioxide (PaCO2). PaO2 was significantly decreased 4 days after OSS… Show more
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