Respiratory allergy to peach leaves and lipid‐transfer proteins

García, Blanca E.; Lombardero, M.; Echechipía, S.; Olaguíbel, J M; Díaz‐Perales, Araceli; Sánchez‐Monge, Rosa; Barber, Domingo; Salcedo, Gabriel; Tabar, A. I.

doi:10.1111/j.1365-2222.2004.01871.x

Cited by 44 publications

(38 citation statements)

References 29 publications

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“…Interestingly we also found similar levels of expression for Pru p 3.03 and Pru p3.01, indicating that both might be involved in peach pollen allergy. A similar amount of LTP (Mal d 3) in peach leaf and fruit skin has been previously reported (GarcÌa et al 2004), and our results show that two isoallergens Pru p 3.01 and Pru p 3.02 might be present.…”

Section: Predominant Isoallergens Involved In Peach Allergysupporting

confidence: 83%

Differential transcript abundance and genotypic variation of four putative allergen-encoding gene families in melting peach

Yang

Chen

et al. 2011

Tree Genetics & Genomes

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Section: Predominant Isoallergens Involved In Peach Allergysupporting

confidence: 83%

Differential transcript abundance and genotypic variation of four putative allergen-encoding gene families in melting peach

Yang

Chen

et al. 2011

Tree Genetics & Genomes

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“…1). We used intranasal routes instead of oral for several reasons: (i) dose of protein needed13, (ii) the intrinsic tolerogenic capacity of the gastrointestinal route161730 and (iii) the capacity of Pru p 3 to sensitise patients through inhalation313233343536. One week after the final sensitisation, all mouse groups (including untreated mice) were challenged with Pru p 3 (100 μg) by intraperitoneal injection.…”

Section: Resultsmentioning

confidence: 99%

“…In the case of peach allergy, although it has been associated with the oral and gastrointestinal routes, some authors found a limited IgE antibody response that could be the consequence of the tolerance mechanisms associated with these routes1617. Moreover, food allergic reactions may also develop following airborne sensitisation and/or challenge, as shown by Pru p 3 which can sensitise patients through both the oral and inhalational routes313233343536.…”

Section: Discussionmentioning

confidence: 99%

LPS promotes Th2 dependent sensitisation leading to anaphylaxis in a Pru p 3 mouse model

Rodríguez

Aranda

Fernández

et al. 2017

Sci Rep

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Pru p 3 is the major peach allergen in the Mediterranean area. It frequently elicits severe reactions, limiting its study in humans, raising the need for animal models to investigate the immunological mechanisms involved. However, no anaphylaxis model exists for Pru p 3. We aimed to develop a model of peach anaphylaxis by sensitising mice with Pru p 3 in combination with lipopolysaccharide (LPS) as an adjuvant. Four groups of mice were sensitised intranasally: untreated; treated with Pru p 3; treated with LPS; treated with Pru p 3 + LPS. After sensitisation mice were intraperitoneally challenged with Pru p 3 and in vivo and in vitro parameters were evaluated. Only mice in the Pru p 3 + LPS group showed anaphylaxis symptoms, including a decrease in temperature. Determination of in vitro parameters showed a Th2 response with an increase of Pru p 3-specific IgE and IgG1. Moreover, at the cellular level, we found increased levels of IgE and IgG1 secreting Pru p 3-specific cells and a proliferative CD4+ T-cell response. These results demonstrate that Pru p 3-specific anaphylaxis can be generated after nasal sensitisation to Pru p 3 in combination with LPS. This is a promising model for evaluating food allergy immunotherapies.

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“…Lombardero and co-workers suggested that in some patients primary sensitization occurs against Art v 3, a LTP present in mugwort pollen [38], although others concluded that such sensitization follows peach sensitization [39]. Sensitization via the inhalation of Pru p 3 derived from peach leaves has been suggested to precede the clinical expression induced by the allergen via the oral route [40]. A woman employed in a fruit and vegetable wholesale store developed rhinitis and asthma in the workplace well before becoming allergic to fruits [41].…”

Section: Evidence For Adult Extra-intestinal Sensitization To Food Almentioning

confidence: 99%

Does Sensitization to Foods in Adults Occur Always in the Gut?

Asero

Antonicelli²

2011

Int Arch Allergy Immunol

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It is widely accepted that, under normal conditions, the contact between allergens and the immune system via the gut results in immune tolerance. Thus, it is rather surprising that normal adults may become sensitized to foods that they have consumed a number of times without any consequence. However, the medical literature is crowded with reports suggesting that sensitization to food allergens may occur outside the intestinal tract in many instances. The present article reviews and discusses current data suggesting, either directly or indirectly, a possible initiation of food allergy in the respiratory tract or in the skin in the light of recent findings about mechanisms of tolerance and sensitization.

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Respiratory allergy to peach leaves and lipid‐transfer proteins

Abstract: Pru p 3 from peach leaves can act as a respiratory allergen and cause occupational rhinoconjunctivitis and asthma.

Cited by 44 publications

References 29 publications

Differential transcript abundance and genotypic variation of four putative allergen-encoding gene families in melting peach

Differential transcript abundance and genotypic variation of four putative allergen-encoding gene families in melting peach

LPS promotes Th2 dependent sensitisation leading to anaphylaxis in a Pru p 3 mouse model

Does Sensitization to Foods in Adults Occur Always in the Gut?

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