Respiration, Physiologic Principles and Their Clinical Applications

Rossier, Paul; Wiesinger, K

doi:10.1097/00000441-196108000-00034

Cited by 14 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Functional residual capacity (FRC) was obtained by the helium dilution method and residual volume (RV) and total lung capacity (TLC) were calculated by concomitantly performed spirometry. Per cent predicted values of VC, DL,CO, FRC, RV and TLC were calculated according to predictive literature data [13][14][15][16][17].…”

Section: Pulmonary Function Testsmentioning

confidence: 99%

Interstitial pulmonary disorders in indium-processing workers

Chonan

Taguchi

Omae³

2006

European Respiratory Journal

108

View full text Add to dashboard Cite

The production of indium-tin oxide has increased, owing to the increased manufacture of liquid-crystal panels. It has been reported that interstitial pneumonia occurred in two indium-processing workers; therefore, the present study aimed to evaluate whether interstitial pulmonary disorders were prevalent among indium workers. The study was carried out in 108 male workers in the indium plant where the two interstitial pneumonia patients mentioned above were employed, and included high-resolution computed tomography (HRCT) of the lungs, pulmonary function tests and analysis of serum sialylated carbohydrate antigen KL-6 and the serum indium concentration. Significant interstitial changes were observed in 23 indium workers on HRCT and serum KL-6 was abnormally high (>500 U x mL(-1)) in 40 workers. Workers with serum indium concentrations in the highest quartile had significantly longer exposure periods, greater HRCT changes, lower diffusing capacity of the lung for carbon monoxide and higher KL-6 levels compared with those in the lowest quartile. The serum indium concentration was positively correlated with the KL-6 level and with the degree of HRCT changes. In conclusion, the results of the present study indicated that serum KL-6 and high-resolution computed tomography abnormalities were prevalent among indium workers and that these abnormalities increased with the indium burden, suggesting that inhaled indium could be a potential cause of occupational lung disease.

show abstract

Section: Pulmonary Function Testsmentioning

confidence: 99%

Interstitial pulmonary disorders in indium-processing workers

Chonan

Taguchi

Omae³

2006

European Respiratory Journal

108

View full text Add to dashboard Cite

show abstract

“…4 The most recent evidence indicates a positive correlation between the vasoconstrictor response and the presence of This work was supported in part by U. S. Public Health Service Grants HE-06285 and HE-5251, the California Tuberculosis and Health Association and Nonr Contract 222(55).…”

Section: Additional Abstract Altitudementioning

confidence: 99%

Response of Small Pulmonary Arteries to Unilobar Hypoxia and Hypercapnia

Kato

Staub

1966

Circulation Research

200

View full text Add to dashboard Cite

We measured the internal diameters of small muscular pulmonary arteries in the right and left lower lobes of lungs rapidly frozen in the anesthetized, open-thorax cat. In every cat the right lower lobe was ventilated with the test gas and all other lobes were ventilated with O 2 . In 4 cats, the test gas supplied to the right lower lobe was also O 2 (control experiments); in 6, it was 100% N 2 and in 6 it was 90% N 2 -10% CO 2 . In the 4 controls, there was no difference between the internal diameters of corresponding arteries in the right and left lower lobes. In the other 12 cats, there was a highly significant decrease in the diameter of arteries in the right lower lobe that correlated well with a large decrease in blood flow to that lobe, calculated using a shunt equation. Ventilation of the right lower lobe with 10% CO 2 in air (4 cats) did not affect the diameter of arteries and ligation of the pulmonary artery to the right lower lobe resulted in only a slight decrease in arterial dimensions in 3 of 4 cats.These data show that in regional alveolar hypoxia without systemic hypoxia the muscular pulmonary arteries of the terminal respiratory units in the hypoxic region actively constrict. The constriction occurs with or without alveolar hypercapnia. ADDITIONAL KEY WORDS altitudecarbon dioxide lung oxygen pulmonary artery pulmonary circulation respiration local regulation of pulmonary circulation pulmonary vasoconstriction hypoxia hypercapnia pulmonary artery occlusion anesthetized cats• Most investigators now agree that reduced partial pressure of oxygen in alveolar air leads to an acute increase in pulmonary vascular resistance in several species of mammal, including man.1 -2 The vasoconstriction occurs both when decreased oxygen is not associated with increased carbon dioxide concentration, as at high altitude, 8 and when the two occur together, as during hypoventilation at sea level. 4 The most recent evidence indicates a positive correlation between the vasoconstrictor response and the presence of This work was supported in part by U. S. Public Health Service Grants HE-06285 and HE-5251, the California Tuberculosis and Health Association and Nonr Contract 222(55).Dr. Kato was a Trainee of the National Heart Institute.Accepted for publication April 11, 1966. both alveolar hypoxia and mixed venous blood (tissue) acidosis. 5A constrictor response can be mediated entirely within the lung, for it can be induced in isolated perfused lungs.6 ' 7i 8 In intact animals, when one lung breathes air low in oxygen but systemic hypoxia is prevented by having the other lung breathe a mixture rich in oxygen, the constriction is confined to the hypoxic lung. 9 ' 10 As to the location of the change in resistance, the major pulmonary vascular resistance normally 11 ' 12 and during alveolar hypoxia is in vessels beyond the tip of any catheter.8 ' 18 The control site must be somewhere in the small muscular pulmonary arteries, 14 "18 the capillaries 17 or small veins. ' 18~21All of these vessels are exposed to t...

show abstract

“…"Manifest respiratory insufficiency" is used by the leading Swiss school (Rossier at al., 1960) to describe patients with arterial desaturation at rest, a usage that seems to have been adopted in Germany (Heilmeyer, 1960). Leading Dutch (Sluiter et al, 1964), French (Sadoul and Lacoste, personal communication), and Swedish (Birath, personal communication) authorities observe definitions almost identical with that put forward here.…”

Section: Other Definitionsmentioning

confidence: 99%