Respirable nanocarriers as a promising strategy for antitubercular drug delivery

Mehanna, Mohammed M.; Mohyeldin, Salma M.; Elgindy, Nazik A.

doi:10.1016/j.jconrel.2014.05.038

Cited by 103 publications

(54 citation statements)

References 120 publications

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“…1 According to the World Health Organization reports, TB together with the acquired immunodeficiency syndrome and malaria are the most fatal diseases worldwide; therefore, better management must be assessed. 1 The current TB therapy possesses many obstacles as the oral drug administration requires a prolonged time over 6-9 months resulting in a poor patient compliance. 2 For decades, TB is treated by first-line anti-TB drugs regimen, which include isoniazid, rifampicin (RIF), pyrazinamide, and ethambutol.…”

Section: Introductionmentioning

confidence: 99%

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The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity

Mohyeldin

Mehanna

Elgindy

2016

IJN

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Purpose This article investigated the influence of novel rifampicin nanosuspension (RIF NS) for enhancing drug delivery properties. Methods RIF NS was fabricated using the antisolvent precipitation technique. The impact of solvent type and flow rate, stabilizer type and concentration, and stirring time and apparatus together with the solvent–antisolvent volume ratio on its controlled nanocrystallization has been evaluated. NSs were characterized by transmission electron microscopy, particle size and zeta potential analysis, solubility, and dissolution profiles. The compatibility between RIF and the stabilizer was investigated via Fourier transform infrared spectroscopy and the differential scanning calorimetry techniques. The shelf-life stability of the RIF NS was assessed within a period of 3 months at different storage temperatures. Cell cytotoxicity was evaluated using 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on lung epithelial cells. Results Polyvinyl alcohol at 0.4% w/v, 1:15 methanol to deionized water volume ratio and 30-minutes sonication were the optimal parameters for RIF NS preparation. Nanocrystals were obtained with a nanometeric particle size (101 nm) and a negative zeta potential (−26 mV). NS exhibited a 50-fold enhancement in RIF solubility and 97% of RIF was dissolved after 10 minutes. The RIF NS was stable at 4±0.5°C with no significant change in particle size or zeta potential. The MTT cytotoxicity assay of RIF NS demonstrated a good safety profile and reduction in cell cytotoxicity with half maximal inhibitory concentration values of 0.5 and 0.8 mg/mL for free RIF and RIF NS, respectively. Conclusion A novel RIF NS could be followed as an approach for enhancing RIF physicochemical characteristics with a prominence of a safer and better drug delivery.

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Section: Introductionmentioning

confidence: 99%

“…Treatment of such cases is much more difficult; the therapy is based on second-line agents that include amino glycoside antibiotics, cycloserine, ethionamide, and fluoroquinolones. 1,2 Conversely, these agents are more…”

Section: Introductionmentioning

confidence: 99%

The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity

Mohyeldin

Mehanna

Elgindy

2016

IJN

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“…In the last case the drug-loaded particles plays the role of the Table 2 Structures, minimum inhibitory concentration and mechanism of action of anti-TB drugs. For doses and routes of administration see Table 1 of (Mehanna et al, 2014).…”

Section: Inhalable Dry Powder Formulations For Tb Treatmentmentioning

confidence: 99%

“…Besides the advances obtained using microparticles, researchers also have considered nanoparticles for antitubercular inhaled therapy (Table 5) as reviewed previously (Andrade et al, 2013;Mehanna et al, 2014). Inhalable nanoparticles can achieve a high drug loading , a better mucosal cell adherence, hence, enhancing net drug delivery to the lungs (Pandey and Khuller, 2005a).…”

Section: Nanoparticlesmentioning

confidence: 99%

Pulmonary drug delivery systems for tuberculosis treatment

Pham

Fattal

2015

International Journal of Pharmaceutics

156

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“…There are many reports emphasizing the need for inhalation formulation for treating tuberculosis (TB) [28]. The widely accepted mode of TB treatment is prolonged intake of fixed dose combination (FDC) tablet containing rifampicin, isoniazid, ethambutol and pyrazinamide.…”

Section: Introductionmentioning

confidence: 99%

Cationic, amphiphilic dextran nanomicellar clusters as an excipient for dry powder inhaler formulation

Vadakkan

Raj

et al. 2015

Acta Biomaterialia

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Respirable nanocarriers as a promising strategy for antitubercular drug delivery

Cited by 103 publications

References 120 publications

The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity

The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity

Pulmonary drug delivery systems for tuberculosis treatment

Cationic, amphiphilic dextran nanomicellar clusters as an excipient for dry powder inhaler formulation

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