Resource Use and Morbidities in Pediatric Cardiac Surgery Patients with Genetic Conditions

Furlong-Dillard, Jamie; Bailly, David K.; Amula, Venugopal; Wilkes, Jacob; Bratton, Susan L.

doi:10.1016/j.jpeds.2017.09.085

Cited by 14 publications

(26 citation statements)

References 42 publications

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“…Furlong-Dillard et al [40] found overall the median LOS in patients with Trisomy 21 was the same as patients without a diagnosed genetic condition at seven days. Comparing patients who ultimately died, the median LOS diverges, but not to a statistically significant level, with Trisomy 21 patients at 36 days as compared with 29 days in those without a diagnosis [40]. Patients with Trisomy 21 do not seem to have an increased risk of readmission [38].…”

Section: Length Of Stay and Readmissionmentioning

confidence: 95%

Section: Length Of Stay and Readmissionmentioning

confidence: 97%

“…Patients with Trisomy 21 overall seem to have comparable or even decreased LOS compared with their peers [17,39,40]. Furlong-Dillard et al [40] found overall the median LOS in patients with Trisomy 21 was the same as patients without a diagnosed genetic condition at seven days. Comparing patients who ultimately died, the median LOS diverges, but not to a statistically significant level, with Trisomy 21 patients at 36 days as compared with 29 days in those without a diagnosis [40].…”

Section: Length Of Stay and Readmissionmentioning

confidence: 97%

“…Patients with 22qDS or Trisomy 13 or Trisomy 18 had the longest median LOS at 18 days and 17 days, respectively [40]. Patients with 'other' genetic conditions or Turner Syndrome had a median LOS of 11 days and 10 days respectively [40].…”

Section: Length Of Stay and Readmissionmentioning

confidence: 99%

See 3 more Smart Citations

Variants of significance: medical genetics and surgical outcomes in congenital heart disease

Geddes

Przybylowski

Ware

2020

Current Opinion in Pediatrics

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Purpose of review-This article reviews the current understanding and limitations in knowledge of the effect genetics and genetic diagnoses have on perioperative and postoperative surgical outcomes in patients with congenital heart disease (CHD).Recent findings-Presence of a known genetic diagnosis seems to effect multiple significant outcome metrics in CHD surgery including length of stay, need for extracorporeal membrane oxygenation, mortality, bleeding, and heart failure. Data regarding the effects of genetics in CHD is complicated by lack of standard genetic assessment resulting in inaccurate risk stratification of patients when analyzing data. Only 30% of variation in CHD surgical outcomes are explained by currently measured variables, with 2.5% being attributed to diagnosed genetic disorders, it is thought a significant amount of the remaining outcome variation is because of unmeasured genetic factors.Summary-Genetic diagnoses clearly have a significant effect on surgical outcomes in patients with CHD. Our current understanding is limited by lack of consistent genetic evaluation and assessment as well as evolving knowledge and discovery regarding the genetics of CHD. Standardizing genetic assessment of patients with CHD will allow for the best risk stratification and ultimate understanding of these effects.

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Section: Length Of Stay and Readmissionmentioning

confidence: 95%

Section: Length Of Stay and Readmissionmentioning

confidence: 97%

Section: Length Of Stay and Readmissionmentioning

confidence: 97%

Section: Length Of Stay and Readmissionmentioning

confidence: 99%

See 2 more Smart Citations

Variants of significance: medical genetics and surgical outcomes in congenital heart disease

Geddes

Przybylowski

Ware

2020

Current Opinion in Pediatrics

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“…There was an anatomic increase in reoperation incidences, such as a small left ventricle (LV) and a double orifice left atrioventricular valve [41]. The hospital resources usage for cardiac surgery in pediatric patients with CHD and genetic conditions is of great interest [42]. Patients with DS and AVSD heart defect did not constitute an extra financial burden due to good surgical outcome and short hospital stay.…”

Section: Complete Atrioventricular Septal Defectmentioning

confidence: 99%

Congenital Heart Disease and Surgical Outcome in Down Syndrome

Alsuhaymi¹

2022

Down Syndrome and Other Chromosome Abnormalities

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The prevalence of congenital heart disease has accounted for nearly one-third of all significant congenital anomalies worldwide. The first report about an association between cardiac anomalies and Down Syndrome was in (1876). Ten years after discovering of Down Syndrome and the credit of association between congenital cardiac anomalies and mongolism was suggested in (1894) by Garrod. There many studies performed to identify a correlation between genotype and phenotype in Down Syndrome, little is known about cardiovascular phenotype in Down Syndrome. Congenital heart disease is considered one of the highest causes of mortality and morbidity in Down Syndrome compared to patients with the same lesion of non-down. There is a big debate about surgical management and considered them as risk factors of surgery with precaution and recent technology, Down Syndrome considered as a normal patient in prognosis. This chapter aimed to shed the light on congenital heart disease in Down Syndrome and current knowledge in specific mutations associated with them and how the effect of innovative technology and management to treat them end at the same outcome and sometimes better based on recent research and Scoring System.

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Inpatient epidemiology, healthcare utilization, and association with comorbidities of Turner syndrome: A National Inpatient Sample study

Chenbhanich

Ungprasert

Kröner

2023

American J of Med Genetics Pt A

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We aimed to investigate the prevalence, resource utilization, and comorbidities of patients with Turner syndrome (TS) hospitalized in the United States. We identified patients within the Nationwide Inpatient Sample database from the year 2017 to 2019. A propensity‐matched cohort of non‐TS patients from the same database was constructed to serve as comparators. There were 9845 TS patients, corresponding to inpatient prevalence of 10.4 per 100,000 admissions. The most common admission diagnosis was sepsis (27.9%). TS patients had higher inpatient mortality (adjusted odds ratio 2.16, 95% confidence interval 1.57–2.96) and morbidity, including shock, ICU admission, acute kidney injury, systemic inflammatory response syndrome, acute respiratory distress syndrome, and multi‐organ failure. Increased risk of comorbidities, such as stroke, myocardial infarction, autoimmune diseases, and non‐variceal gastrointestinal bleeding, was observed. TS patients had longer length of stay (LOS; 5.1 days vs. 4.5 days, p < 0.01) and displayed a mean additional $5382 (p < 0.01) in total hospital costs and a mean additional $20,083 (p < 0.01) in total hospitalization charges. In conclusion, hospitalization of patients with TS was associated with a significantly higher inpatient morbidity, mortality, expenditures, and longer LOS compared to non‐TS patients. Patients with TS had a higher risk of cardiovascular complications, autoimmune diseases, and gastrointestinal bleeding.

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Resource Use and Morbidities in Pediatric Cardiac Surgery Patients with Genetic Conditions

Cited by 14 publications

References 42 publications

Variants of significance: medical genetics and surgical outcomes in congenital heart disease

Variants of significance: medical genetics and surgical outcomes in congenital heart disease

Congenital Heart Disease and Surgical Outcome in Down Syndrome

Inpatient epidemiology, healthcare utilization, and association with comorbidities of Turner syndrome: A National Inpatient Sample study

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