“…The cost analysis of six studies was based on individual resource use under routine care [ 8 , 10 , 13 , 14 , 21 , 22 ], while two calculated annual costs from the aggregate perspective [ 17 , 18 ]. Only two studies examined different cost categories for outpatient treatment allowing the estimation of costs for health personnel [ 22 , 23 ]. Comparison of our findings with those of other studies addressing CF outpatient costs is not straightforward as the methodology used, perspective adopted, and health service utilization and organization vary.…”