Resource Profile: The Regenstrief Institute COVID-19 Research Data Commons (CoRDaCo)

Abstract

The primary objective of the COVID-19 Research Data Commons (CoRDaCo) is to provide broad and efficient access to a large corpus of clinical data related to COVID-19 in Indiana, facilitating research and discovery. This curated collection of data elements provides information on a significant portion of COVID-19 positive patients in the State from the beginning of the pandemic, as well as two years of health information prior its onset. CoRDaCo combines data from multiple sources, including clinical data from a large, regional health information exchange, clinical data repositories of two health systems, and state laboratory reporting and vital records, as well as geographic-based social variables. Clinical data cover information such as healthcare encounters, vital measurements, laboratory orders and results, medications, diagnoses, the Charlson Comorbidity Index and Pediatric Early Warning Score, COVID-19 vaccinations, mechanical ventilation, restraint use, intensive care unit and ICU and hospital lengths of stay, and mortality. Interested researchers can visit ridata.org or email askrds@regenstrief.org to discuss access to CoRDaCo.

Understanding comorbidities and health disparities related to COVID-19: a comprehensive study of 776 936 cases and 1 362 545 controls in the state of Indiana, USA

“…When compared to all COVID-19 patients, there were some differences observed among the COVID-19 patients with COPD. First, ICU admission rate for COVID-19 patients with COPD was significantly higher (10.23% vs 1.94% 43 ) indicating that COPD was a strong risk factor; second, the death rate among COVID-19 patients with COPD was significantly higher (8.22% vs 2.24% 43 ).…”

“…Additional results are presented in the Supplementary Materials . CoRDaCo data characteristics can be found in Allen et al 43 …”

“…EHR data were obtained from the COVID-19 Research Data Commons (CoRDaCo). 43 CoRDaCo was created and is managed by the Regenstrief Institute to efficiently collect, manage, and analyze datasets related to COVID-19 for research. CoRDaCo contains data from 3 sources: the Indiana Network for Patient Care (INPC) managed by the Indiana Health Information Exchange, and the clinical data warehouses of Indiana University Health and Eskenazi Health.…”

“…Collected data included demographics, diagnoses, laboratory results, medications, inpatient and outpatient encounter information including ICU status, and mortality for all patients. 43 In total, there were 776 759 COVID-19 positive patients and 1 362 527 COVID-19 negative patients between ages 0 and 110 years. Supplementary Figure S1 presents an overview of how the COVID-19 positive patient cohort was labeled and divided into groups based on comorbidities and ICU admission.…”

“…A patient was given a label of “ICU” if the patient had an ICU encounter after March 6, 2020 (ie, the date of COVID-19 appearance in Indiana). Following such labeling scheme, in total, there were 15 084 cases and 35 743 controls labeled “ICU.” 43 Patients were considered to have a comorbidity if the patient had a diagnosis of the comorbidity prior to their date of COVID-19 diagnosis or March 6, 2020 if they did not have a recorded COVID-19 diagnosis date. A more severe case of COVID-19 is considered as the one which resulted in an ICU admission.…”