Resource allocation in biochemically structured metabolic networks
Leon Seeger,
Fernanda Pinheiro,
Michael Lässig
Abstract:Microbes tune their metabolism to environmental challenges by changing protein expression levels, metabolite concentrations, and reaction rates simultaneously. Here, we establish an analytical model for microbial resource allocation that integrates enzyme biochemistry and the global architecture of metabolic networks. We describe the production of protein biomass from external nutrients in pathways of Michaelis-Menten enzymes and compute the resource allocation that maximizes growth under constraints of mass c… Show more
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