Resorption of synthetic porous hydroxyapatite and replacement by newly formed bone

Goto, Takahiro; Kojima, Tatsuyoshi; Iijima, Tadahiko; Yokokura, Satoshi; Kawano, Hirotaka; Yamamoto, Aiichiro; Matsuda, Koichi

doi:10.1007/s007760170013

Cited by 54 publications

(43 citation statements)

References 14 publications

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“…These activities can probably be ascribed to ion released after clast (osteoclast-like cells) resorption of microliths. Though several authors have documented resorption of hydroxyapatite (Gomi et al, 1993;Piattelli et al, 1993;Overgaard et al, 1996Overgaard et al, , 1997Overgaard et al, , 1998Goto et al, 2001), most studies refer to the results of implants of nonresorbable hydroxyapatite (Zeller et al, 1986;Klinge et al, 1992;Hoad-Reddick et al, 1994;Nemcovsky and Serfaty, 1996;Piattelli et al, 1998;Rafter et al, 2002). Particularly in dentistry, the use of this term generates confusion for the end users, who is led to believe that there are two types of hydroxyapatites: non-resorbable and resorbable.…”

Section: Osteoinductive Capabilitymentioning

confidence: 93%

Some considerations on biomaterials and bone

Zaffe

2005

Micron

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Section: Osteoinductive Capabilitymentioning

confidence: 93%

Some considerations on biomaterials and bone

Zaffe

2005

Micron

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“…The disadvantages in using metallic implants for the fixation of the fracture also include stress shielding in the region of the implant, inflammatory reaction, and foreign body reaction [3]. Large bone defects coupled with non-union, or misalignment, of the fractured components can cause pain and dysfunction, thereby necessitating the need for use of allograft or autograft as bone inductive agents for the purpose of bone repair [1][2][3]. The allograft utilizes frozen bones for the purpose of bone repair and regeneration and possesses intrinsic limitations such as disease transmission and immunological reactions.…”

Section: Introductionmentioning

confidence: 99%

“…Orthopedic surgeries using implants for replacing the diseased bone or stabilizing the fracture pose a medical challenge that often necessitates the need for a second surgical procedure to facilitate the removal of fractured components [1,2]. The disadvantages in using metallic implants for the fixation of the fracture also include stress shielding in the region of the implant, inflammatory reaction, and foreign body reaction [3].…”

Section: Introductionmentioning

confidence: 99%

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Processing Methodologies for Polycaprolactone-Hydroxyapatite Composites: A Review

Baji¹,

Wong²,

Srivatsan³

et al. 2006

Materials and Manufacturing Processes

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Biodegradable implants have shown great promise for the repair of bone defects and have been commonly used as bone substitutes, which traditionally would be treated using metallic implants. The need for a second surgery exacerbated by the stress shielding effect caused by an implant has led researchers to consider more effective, synthetic biodegradable graft substitutes. The hierarchical structures commonly designed are inspired by nature in human bones, which consist of minerals such as hydroxyapatite, a form of calcium phosphate and protein fiber. The bone graft bio-substitutes should possess a combination of properties for the purpose of facilitating cell growth and adhesion, a high degree of porosity, which would facilitate the transfer of nutrients and excretion of the waste products, and the scaffold should have high tensile strength and high toughness in order to be consistent with human tissues. Blending of polycaprolactone and hydroxyapatite has demonstrated great potential as bone substitutes. It is essential to identify a standardized processing methodology for the composite, which would result in optimum mechanical property for the biocomposite. In this study, biocomposites made of polycaprolactone (PCL) and hydroxyapatite (HAP) are reviewed for their applications in bone tissue engineering. The processing methodologies are discussed for the purpose of obtaining the porosity and pore size required in an ideal tissue scaffold. The properties of the composite can be varied based on the change in pore size, porosity, and processing methodology. This paper reviews and evaluates the methods to produce the hydroxyapatite-polycaprolactone scaffolds.

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“…HA is a class of bioceramic material frequently used in bone grafting [2][3][4] and in bone drug delivery [5][6][7] . It is one of the most widely used biomaterials for various bone applications because it possesses most of the qualities required for bone tissue formation.…”

Section: Synthesis Of Nanophase Hamentioning

confidence: 99%

Development of Cell-Responsive Nanophase Hydroxyapatite for Tissue Engineering

Murugan¹,

Ramakrishna²

2007

American J. of Biochemistry and Biotechnology

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Scaffold plays a critical role in engineering bone tissues by providing necessary structural support for the cells to accommodate and guiding their growth in the three dimensional (3D) space. Therefore, designing scaffold that mimic composition and structural aspects of the bone is of great importance to promote cell adhesion, cell-matrix interactions, osteointegration, tissue formation and continued function. Nanophase hydroxyapatite (HA) is a class of bioceramic material that mimics the bone mineral in composition and structure and possesses unique capabilities for surface interactions with biological entities than conventional HA; therefore, it can be used as a scaffolding system in engineering bone tissues. This article reports synthesis, characterization, and evaluation of nanophase HA for use in bone tissue engineering and how the nanophase characteristics help the HA to promote cells/tissue growth with suitable experimental examples.

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Resorption of synthetic porous hydroxyapatite and replacement by newly formed bone

Cited by 54 publications

References 14 publications

Some considerations on biomaterials and bone

Some considerations on biomaterials and bone

Processing Methodologies for Polycaprolactone-Hydroxyapatite Composites: A Review

Development of Cell-Responsive Nanophase Hydroxyapatite for Tissue Engineering

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