Resorbable synthetic polymers s replacements for bone graft

Coombes, Allan G.A.; Meikle, Murray C.

doi:10.1016/0267-6605(94)90046-9

Cited by 152 publications

(106 citation statements)

References 92 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…The list of synthetic biodegradable polymers used for biomedical application as scaffold materials is available as Table 1 in Ref. [142], while further details on polymers suitable for biomedical applications are available in the literatures [97,134,[143][144][145][146][147][148][149][150][151] where the interested readers are referred. Good reviews on the synthesis of different biodegradable polymers [152], as well as on the experimental trends in polymer nanocomposites [153] are available elsewhere.…”

Section: Polymersmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

275

142

View full text Add to dashboard Cite

show abstract

Section: Polymersmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

275

142

View full text Add to dashboard Cite

show abstract

“…In principle, a biodegradable matrix with sufficient mechanical strength, optimized architecture and suitable degradation rate, which could finally be replaced by newly formed bone, is most desirable. Over the past decade, the main goal of bone tissue engineering has been to develop biodegradable materials as bone graft substitutes for filling large bone defects [1][2][3].…”

mentioning

confidence: 99%

Preparation and Properties of Poly(lactide-co-glycolide) (PLGA)/ Nano-Hydroxyapatite (NHA) Scaffolds by Thermally Induced Phase Separation and Rabbit MSCs Culture on Scaffolds

Huang¹,

Ren

Chen³

et al. 2007

J Biomater Appl

119

View full text Add to dashboard Cite

Biodegradable polymer/bioceramic composites scaffold can overcome the limitation of conventional ceramic bone substitutes such as brittleness and difficulty in shaping. To better mimic the mineral component and the microstructure of natural bone, novel nano-hydroxyapatite (NHA)/polymer composite scaffolds with high porosity and well-controlled pore architectures as well as high exposure of the bioactive ceramics to the scaffold surface is developed for efficient bone tissue engineering. In this article, regular and highly interconnected porous poly(lactide-co-glycolide) (PLGA)/NHA scaffolds are fabricated by thermally induced phase separation technique. The effects of solvent composition, polymer concentration, coarsening temperature, and coarsening time as well as NHA content on the micro-morphology, mechanical properties of the PLGA/NHA scaffolds are investigated. The results show that pore size of the PLGA/NHA scaffolds decrease with the increase of PLGA concentration and NHA content. The introduction of NHA greatly increase the mechanical properties and water absorption ability which greatly increase with the increase of NHA content. Mesenchymal stem cells are seeded and cultured in *Author to whom correspondence should be addressed. E-mail: renjie@mail.tongji.edu.cn three-dimensional (3D) PLGA/NHA scaffolds to fabricate in vitro tissue engineering bone, which is investigated by adhesion rate, cell morphology, cell numbers, and alkaline phosphatase assay. The results display that the PLGA/NHA scaffolds exhibit significantly higher cell growth, alkaline phosphatase activity than PLGA scaffolds, especially the PLGA/NHA scaffolds with 10 wt.% NHA. The results suggest that the newly developed PLGA/NHA composite scaffolds may serve as an excellent 3D substrate for cell attachment and migration in bone tissue engineering.

show abstract

“…However, the combination of these cements with stem cells has not been fully explored. Finally, many studies now employ the use of organic synthetic scaffolds based on alpha-hydroxy acids (23,24). These scaffolds are usually composed of polyglycolic acid, poly-L-lactic acid or a combination of both (i.e., PLGA) possess limited osteoconductive capacity but when combined with HA technologies become excellent materials for bone repair by stem cells.…”

Section: Pick a Scaffold Any Scaffoldmentioning

confidence: 99%

Tissue Engineering Craniofacial Defects With Adult Stem Cells? Are We Ready Yet?

Zuk

2008

Pediatr Res

View full text Add to dashboard Cite

Over three-quarters of all craniofacial defects observed in the US per year are cleft palates. Usually involving significant bony defects in both the hard palate and alveolar process of the maxilla, repair of these defects is typically performed surgically using autologous bone grafts taken from appropriate sites (i.e., iliac crest). However, surgical intervention is not without its complications. As such, the reconstructive surgeon has turned to the scientist and engineer for help. In this review, the application of the field of tissue engineering to craniofacial defects (e.g., cleft palates) is discussed. Specifically the use of adult stem cells, such as mesenchymal stem cells from bone marrow and Adipose-derived Stem Cells (ASCs) in combination with currently available biomaterials is presented in the context of healing craniofacial defects like the cleft palate. Finally, future directions with regards to the use of ASCs in craniofacial repair are discussed, including possible scaffold-driven and gene-driven approaches. (Pediatr Res 63: 478-486, 2008)

show abstract

Resorbable synthetic polymers s replacements for bone graft

Cited by 152 publications

References 92 publications

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Preparation and Properties of Poly(lactide-co-glycolide) (PLGA)/ Nano-Hydroxyapatite (NHA) Scaffolds by Thermally Induced Phase Separation and Rabbit MSCs Culture on Scaffolds

Tissue Engineering Craniofacial Defects With Adult Stem Cells? Are We Ready Yet?

Contact Info

Product

Resources

About