Resorbable elastomeric networks prepared by photocrosslinking of high-molecular-weight poly(trimethylene carbonate) with photoinitiators and poly(trimethylene carbonate) macromers as crosslinking aids

Bat, Erhan; Kooten, Theo G. van; Feijén, Jan; Grijpma, Dirk W.

doi:10.1016/j.actbio.2011.01.010

Cited by 43 publications

(51 citation statements)

References 53 publications

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“…The originality of this work is to introduce SLA‐fabricated PTMC/HA composite scaffold in the field of bone tissue engineering. Using PTMC as porous matrix could potentially bring advantages compared with polyesters, as no acid by‐product is released upon PTMC degradation …”

Section: Resultsmentioning

confidence: 99%

Poly(trimethylene carbonate) and nano‐hydroxyapatite porous scaffolds manufactured by stereolithography

Guillaume

Geven

Grijpma

et al. 2016

Polymers for Advanced Techs

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Designing calcium phosphate‐loaded polymeric porous scaffolds with controlled architecture using stereolithography (SLA) has great potential in the field of bone tissue engineering. However, the use of poly(ester)s with suboptimal degradation property has mainly been reported. In the present work, we introduced a poly(trimethylene carbonate) (PTMC) and nano‐hydroxyapatite (HA) resin suitable for SLA manufacturing and created cytocompatible 3D porous structure. First, the resin formulation and HA content were optimized for photo‐crosslink‐based SLA fabrication process. Subsequently, we evaluated the influence of the resin composition on physico‐chemical characteristics of fabricated films and scaffolds. Then, the influence of the biomaterial composition on human bone marrow mesenchymal stem cell viability, adhesion and proliferation was assessed. Films and macroporous scaffolds were successfully produced by photo‐crosslinking with up to 40 wt% of HA (relative to PTMC). We demonstrated that addition of HA in PTMC matrices induced a direct effect on the surface properties, in terms of wettability and topography. Additionally, mechanical tests revealed a correlation between the amounts of HA loaded in PTMC and the stiffness of the SLA‐fabricated scaffolds. Importantly, the different photo‐crosslinked biomaterials exhibited in vitro cytocompatibility, similar to tissue culture polystyrene. Those data suggest the possibility to fabricate highly tunable HA‐loaded PTMC 3D porous structures for bone tissue engineering application. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Poly(trimethylene carbonate) and nano‐hydroxyapatite porous scaffolds manufactured by stereolithography

Guillaume

Geven

Grijpma

et al. 2016

Polymers for Advanced Techs

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“…Compared to crosslinking macromers of high molecular weight, crosslinking macromers of lower molecular weight results in shorter chains between crosslinks, and increased crosslinking density. This reduced length of PTMC network chains could explain the observed difference in degradation rates between the different networks, by limiting accessibility and optimal chain conformations for enzymatic attack …”

Section: Discussionmentioning

confidence: 99%

“…Speeding up degradation rates would be possible by photo‐crosslinking PTMC‐tMA macromers of even higher molecular weights (i.e. higher than 30 kg/mol) . However, using initial macromers of high(‐er) molecular weight poses challenges in processing the macromer by stereolithography.…”

Section: Discussionmentioning

confidence: 99%

“…In view of these outlined properties, photo‐crosslinking PTMC‐tMA with relatively high molecular weight results in attractive materials well suited for the engineering of an anatomically correct meniscus scaffold. However, the molecular weight of the macromers used might influence degradation rate of the final network . Since degradation is an important parameter in the selection process of an optimal material for engineering a meniscus scaffold it is paramount to evaluate the effect of the molecular weight of the macromer on the degradation behavior of the resulting network.…”

Section: Introductionmentioning

confidence: 99%

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Degradation behavior of, and tissue response to photo‐crosslinked poly(trimethylene carbonate) networks

Rongen

Bochove

Hannink

et al. 2016

J Biomedical Materials Res

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Photo-crosslinked networks prepared from three-armed methacrylate functionalized PTMC oligomers (PTMC-tMA macromers) are attractive materials for developing an anatomically correct meniscus scaffold. In this study, we evaluated cell specific biocompatibility, in vitro and in vivo degradation behavior of, and tissue response to, such PTMC networks. By evaluating PTMC networks prepared from PTMC-tMA macromers of different molecular weights, we were able to assess the effect of macromer molecular weight on the degradation rate of the PTMC network obtained after photo-crosslinking. Three photo-crosslinked networks with different crosslinking densities were prepared using PTMC-tMA macromers with molecular weights 13.3, 17.8, and 26.7 kg/mol. Good cell biocompatibility was demonstrated in a proliferation assay with synovium derived cells. PTMC networks degraded slowly, but statistically significant, both in vitro as well as subcutaneously in rats. Networks prepared from macromers with higher molecular weights demonstrated increased degradation rates compared to networks prepared from initial macromers of lowest molecular weight. The degradation process took place via surface erosion. The PTMC networks showed good tissue tolerance during subcutaneous implantation, to which the tissue response was characterized by the presence of fibrous tissue and encapsulation of the implants. Concluding, we developed cell and tissue biocompatible, photo-crosslinked PTMC networks using PTMC-tMA macromers with relatively high molecular weights. These photo-crosslinked PTMC networks slowly degrade by a surface erosion process. Increasing the crosslinking density of these networks decreases the rate of surface degradation. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2823-2832, 2016.

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“…Owing to the advantages such as nontoxic, biocompatible, excellent mechanical and physicochemical properties, biodegradable hydrogels are regarded as suitable materials for biomedical, pharmaceutical, environmental, and other applications . The effective means to manipulate the structure and properties of hydrogels include varying the polymer composition and controlling the crosslinking process .…”

Section: Introductionmentioning

confidence: 99%

Controllable synthesis of a novel poly(vinyl alcohol)-based hydrogel containing lactate and PEG moieties

Xiao

2013

Polym Eng Sci

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Tunable hydrogel that contained well‐defined poly(vinyl alcohol) (PVA), labile lactate groups, and hydrophilic poly(ethylene glycol) (PEG) segments was prepared through a combination of reversible addition‐fragmentation chain transfer (RAFT) polymerization and esterification reaction. A diol was prepared via the esterification between lactic acid (LA) and PEG. Then the diol was allowed to react with maleic anhydride to produce a diacid. Meanwhile, well‐defined PVA was synthesized by the alcoholysis of poly(vinyl acetate) (PVAc) obtained by RAFT polymerization of vinyl acetate. The hydrogels with tailor‐made structure were generated by crosslinking PVA with LA‐based diacid. The structures and properties of LA‐based intermediates and the hydrogels were characterized with Fourier transform infrared spectroscopy, gel permeation chromatography, differential scanning calorimetry, and thermogravimetric analysis. Both LA‐based diol and diacid were semicrystalline and water‐soluble, their melting temperature and glass transition temperature were 52 and −51, 54 and −41°C, respectively. The polydispersity indexes of the precursor of PVA samples were within the range of 1.03–1.10. It was found that the thermal stability of hydrogel was higher than that of LA‐based diacid. Both the swelling and release properties of the hydrogels depend on the feeding ratio of PVA/LEM and the chain length of PVA, which reflected that the structure and properties of the hydrogels were controllable. POLYM. ENG. SCI., 54:1366–1371, 2014. © 2013 Society of Plastics Engineers

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Resorbable elastomeric networks prepared by photocrosslinking of high-molecular-weight poly(trimethylene carbonate) with photoinitiators and poly(trimethylene carbonate) macromers as crosslinking aids

Cited by 43 publications

References 53 publications

Poly(trimethylene carbonate) and nano‐hydroxyapatite porous scaffolds manufactured by stereolithography

Poly(trimethylene carbonate) and nano‐hydroxyapatite porous scaffolds manufactured by stereolithography

Degradation behavior of, and tissue response to photo‐crosslinked poly(trimethylene carbonate) networks

Controllable synthesis of a novel poly(vinyl alcohol)-based hydrogel containing lactate and PEG moieties

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