Resorbable airway splint, stents, and 3D reconstruction and printing of the airway in tracheobronchomalacia

Bellía-Munzón, Gastón; Cieri, Patricio; Toselli, L; Cuestas, Giselle; Doormann, Flavia; Gabaldón-Massé, Paula; Rodríguez, Verónica; Bellia-Munzon, Patricio

doi:10.1016/j.sempedsurg.2021.151063

Cited by 5 publications

(4 citation statements)

References 62 publications

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“…43 This technology enables the creation of intricate, patient-specific, multi-layered designs tailored to individual tracheal features. 44 Polycaprolactone (PCL), renowned for its exceptional mechanical properties, controllable in vivo degradation, and long-term stability, has been a predominant material in 3D printing TE applications.…”

Section: D Printing Technologymentioning

confidence: 99%

“…The application of 3D printing in medical research has gained traction due to its capability for rapid fabrication of customized substitutes for structural reconstruction, allowing modulation of properties such as architecture, mechanical characteristics, and degradation rate 43 . This technology enables the creation of intricate, patient‐specific, multi‐layered designs tailored to individual tracheal features 44 . Polycaprolactone (PCL), renowned for its exceptional mechanical properties, controllable in vivo degradation, and long‐term stability, has been a predominant material in 3D printing TE applications.…”

Section: Te Strategymentioning

confidence: 99%

“… 43 This technology enables the creation of intricate, patient‐specific, multi‐layered designs tailored to individual tracheal features. 44 Polycaprolactone (PCL), renowned for its exceptional mechanical properties, controllable in vivo degradation, and long‐term stability, has been a predominant material in 3D printing TE applications. Notably, 3D‐printed PCL stents have obtained approval from the United States Food and Drug Administration for emergent use in pediatric operation to address benign lesions.…”

Section: Te Strategymentioning

confidence: 99%

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Tissue‐engineered tracheal implants: Advancements, challenges, and clinical considerations

Wei,

Zhang,

Luo

et al. 2024

Bioengineering & Transla Med

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Restoration of extensive tracheal damage remains a significant challenge in respiratory medicine, particularly in instances stemming from conditions like infection, congenital anomalies, or stenosis. The trachea, an essential element of the lower respiratory tract, constitutes a fibrocartilaginous tube spanning approximately 10–12 cm in length. It is characterized by 18 ± 2 tracheal cartilages distributed anterolaterally with the dynamic trachealis muscle located posteriorly. While tracheotomy is a common approach for patients with short‐length defects, situations requiring replacement arise when the extent of lesion exceeds 1/2 of the length in adults (or 1/3 in children). Tissue engineering (TE) holds promise in developing biocompatible airway grafts for addressing challenges in tracheal regeneration. Despite the potential, the extensive clinical application of tissue‐engineered tracheal substitutes encounters obstacles, including insufficient revascularization, inadequate re‐epithelialization, suboptimal mechanical properties, and insufficient durability. These limitations have led to limited success in implementing tissue‐engineered tracheal implants in clinical settings. This review provides a comprehensive exploration of historical attempts and lessons learned in the field of tracheal TE, contextualizing the clinical prerequisites and vital criteria for effective tracheal grafts. The manufacturing approaches employed in TE, along with the clinical application of both tissue‐engineered and non‐tissue‐engineered approaches for tracheal reconstruction, are discussed in detail. By offering a holistic view on TE substitutes and their implications for the clinical management of long‐segment tracheal lesions, this review aims to contribute to the understanding and advancement of strategies in this critical area of respiratory medicine.

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Section: D Printing Technologymentioning

confidence: 99%

Section: Te Strategymentioning

confidence: 99%

Section: Te Strategymentioning

confidence: 99%

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Tissue‐engineered tracheal implants: Advancements, challenges, and clinical considerations

Wei,

Zhang,

Luo

et al. 2024

Bioengineering & Transla Med

View full text Add to dashboard Cite

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“…57,58 3D-printed medical devices that are already being explored for use in the pediatric patient population are stents, tubes, swabs, and airway support devices that could be created in much smaller sizes to suit the wide range of needs of this population. [57][58][59][60][61] Challenges like very small anatomy size and growth over time must be considered when 3D printing medical devices for this population. Follow-up and replacement of the device must be considered as part of the device implementation.…”

Section: D Printingmentioning

confidence: 99%

Shortages of Care and Medical Devices Affecting the Pediatric Patient Population

Jones,

Walter

2023

cjht

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What Is the Issue? Shortage events, the phenomena when demand exceeds supply, can affect both medical care and medical devices. The COVID-19 pandemic caused a global shortage event, the consequences of which are still being experienced beyond the peak of the pandemic (e.g., the lack of pediatric pain medication available in fall 2022). Children are vulnerable to shortage events as they represent a small proportion of the overall population, have distinct needs, and the pediatric medical device market has historically offered a lack of options. What Are the Technologies? Technologies such as artificial intelligence (AI)-enabled devices, point of care testing, and virtual care options could contribute to alleviating shortages in pediatric care. Technologies such as 3D printing, alternative interventions such as tracheostomy during shortages of mechanical ventilators, and the reprocessing of single use devices such as ventilator tubes have been suggested in times of pediatric medical device shortages. Solutions to shortage events can take the form of novel devices, interventions, or policies; however, due to the complexity of this problem, a multipronged approach is likely needed. What Is the Potential Impact? Shortages can cause delayed intervention, which has health and financial costs. When cancer diagnoses and treatments are delayed, overall survival rates decrease. High-quality early intervention can change a child’s developmental trajectory and improve outcomes for children, families, and communities. Finding solutions to shortages, particularly for children as they are already at risk for health inequities, is crucial to ensure good health care outcomes in the long-term. What Else Should We Know? During a shortage event, alternative interventions may have different safety profiles or require different training than default practices. Equity should be a consideration when implementing technologies, interventions, and policies to address shortage events so that these solutions do not end up replicating or exacerbating existing inequities.

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Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

Brown¹,

Li²,

Moraes³

et al. 2022

Biomaterials

105

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Resorbable airway splint, stents, and 3D reconstruction and printing of the airway in tracheobronchomalacia

Cited by 5 publications

References 62 publications

Tissue‐engineered tracheal implants: Advancements, challenges, and clinical considerations

Tissue‐engineered tracheal implants: Advancements, challenges, and clinical considerations

Shortages of Care and Medical Devices Affecting the Pediatric Patient Population

Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

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