Resonant Oscillation Language of a Futuristic Nano-Machine-Module: Eliminating Cancer Cells & Alzheimer Aβ Plaques

Abstract

Nano-machine-module is designed and synthesized as a futuristic drug (PCMS) for cancer and Alzheimers by doping 2 Nile Red molecules in the cavity of a 5(th) generation PAM AM dendrimer P, and attaching 32 molecular rotors M, 4 pH sensors S on its surface. Molecular rotors and sensors enable the dendritic box surface to target specific sites, minimizing termination of healthy cells, e.g. cancer cells, nuclei acids (DNA) & spirals of Abeta Amyloid are disintegrated. Combined Excitation Emission Spectroscopy (CEES) shows directed energy transfer along M↔C↔S, this energy transmission path is itself an oscillation, and we image live resonant oscillation of the PCMS and the target molecular system. PCMS engages into resonant oscillations with spiral molecular structures. PCMS is designed to sense microsatellite instability & spirals with resonance frequencies in the kHz range. PCM is toxic, but the toxicity disappears as S is added to derive PCMS. PCMS does not even affect the dynamic instability of microtubule, a basic operator of living cells.

In-vivo & in-vitro toxicity test of molecularly engineered PCMS: A potential drug for wireless remote controlled treatment

“…It causes a huge waste of resources over the years in the drug development process. Therefore, since our synthesized PCMS has showed selective activity in targeting the cancer cell nucleotides [ 7 ], then the further study of toxicity and pharmacokinetics became a reason for this study. Many synthetic routes are adopted to resolve the toxicity issues [ [8] , [9] , [10] , [11] ].…”

“…For years, we are developing PAMAM dendrimers (>G3.5) based chemically inert and purely physical analogue [ 7 , [25] , [26] , [27] , [28] ] to the existing chemical drugs, —wirelessly operated by an electromagnetic antenna like remote controller located outside the body. The purely organic device is designed in such a way that it would not release any chemical in the body but physically interact with the target biomolecule in the infected parts with the vibrations in a molecularly precise manner.…”

“…These rotors displace the end charge amine -NH 2 and −COOH terminals which tends to bind with the proteins. These groups are known to damage the cell membrane and cell organelles by unwanted bonding instead of phagocytosis [ 47 ] We reported earlier in detail how motors arrest the unpredictable behavior of PAMAM; [ 7 , [25] , [26] , [27] ]. An ordered dynamic behavior is bearable for the cell to work but an uncontrolled dynamics may trigger unwanted molecular processes in a cell [ 48 ].…”

“…One of the best examples is our PCMS system, where we added only four pH sensor molecules on the PAMAM surface in addition to the 32 molecular rotors; the proton-sensing ability dramatically improves the derivative’s cellular acceptance. We reported [ 7 ] and patented [ [28] , [29] , [30] ] PCMS as a wireless, remotely controlled nanobot for regulating the target molecule's dynamics. As we encapsulated a multi-level switch C [ [49] , [50] , [51] ], Nile red doped inside PAMAM generated a cyclic triangular oscillation or clocking like vibration between the three components (multilevel switch C, pH sensor, S and the motor, M) inside PCMS [ [25] , [26] , [27] ].…”

“…As we encapsulated a multi-level switch C [ [49] , [50] , [51] ], Nile red doped inside PAMAM generated a cyclic triangular oscillation or clocking like vibration between the three components (multilevel switch C, pH sensor, S and the motor, M) inside PCMS [ [25] , [26] , [27] ]. We have already described [ 7 ] how these three components resonant oscillations enable them to mimicking the vibrations of the desired target (mutated DNA, deformed proteins & their accumulation etc.). Resonant oscillations associated with mechanical vibration destroys the material's weak structural bonds [ 7 ] or arrests the molecules key dynamics leading to fatal cellular action in a molecularly precise manner [ 48 ].…”