Resonant acoustic radiation force optical coherence elastography

Qi, Wenjuan; Li, Rui; Ma, Teng; Li, Jiawen; Shung, K. Kirk; Zhou, Qifa; Chen, Zhongping

doi:10.1063/1.4820252

Cited by 57 publications

(78 citation statements)

References 15 publications

(21 reference statements)

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“…Besides, the demonstration of this natural-frequency-based approach is limited to homogeneous tissue samples. Recently, Qi et al have developed a resonant OCE technique that uses the mechanical resonant frequency to map the tissue elastic properties [40]. The depthwise distribution of the sample elasticity is achieved through detecting the vibrational amplitudes from the scattering parts inside the sample at varying driving frequencies.…”

Section: Discussionmentioning

confidence: 99%

Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens

Wang

Aglyamov

Karpiouk

et al. 2013

Biomed. Opt. Express

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Abstract:We demonstrate the feasibility of using the dominant frequency of the sample surface response to a mechanical stimulation as an effective indicator for sensing the depthwise distribution of elastic properties in transparent layered phantom samples simulating the cortex and nucleus of the crystalline lens. Focused ultrasound waves are used to noninvasively interrogate the sample surface. A phase-sensitive optical coherence tomography system is utilized to capture the surface dynamics over time with nanometer scale sensitivity. Spectral analysis is performed on the sample surface response to ultrasound stimulation and the dominant frequency is calculated under particular loading parameters. Pilot experiments were conducted on homogeneous and layered tissuemimicking phantoms. Results indicate that the mechanical layers located at different depths introduce different frequencies to the sample surface response, which are correlated with the depth-dependent elasticity of the sample. The duration and the frequency of the ultrasound excitation are also investigated for their influences on this spectrum-based detection. This noninvasive method may be potentially applied for localized and rapid assessment of the depth dependence of the mechanical properties of the crystalline lens.

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Section: Discussionmentioning

confidence: 99%

Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens

Wang

Aglyamov

Karpiouk

et al. 2013

Biomed. Opt. Express

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“…The resulting displacement has been detected as the axial displacement along the ultrasound beam at focus [83][84][85][86][87] or as an axial displacement associated with a shear wave generated by the burst at some lateral offset from the focus [88][89][90]. By scanning the frequency of the amplitude modulation, it has also been demonstrated that acoustic mechanical resonance can be detected along the axial direction [91]. Shear wave propagation can be characterized in the orthogonal geometry, i.e., with the ultrasound beam orthogonal to the OCT beam [62], a somewhat limiting geometry for general applications, but suited to some [92].…”

Section: Loading Methodsmentioning

confidence: 99%

“…Similarly, sweeping the amplitude modulation frequency of the ultrasound carrier in ARF can provide spectroscopic mechanical contrast in tissue, as shown in Fig. 11, revealing the difference in mechanical properties of loose and dense fibrous caps in arterial walls, based on their resonance frequencies [91]. The extent to which the frequency responses of different regions within the tissue are coupled and how regional properties are affected by sample shape and properties of the boundary have largely yet to be explored (although the effect of sample geometry has been examined in [128,130]), but computational models will undoubtedly be useful in assessing this.…”

Section: Steady-state Harmonic Methodsmentioning

confidence: 99%

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Larin

Sampson

2017

Biomed. Opt. Express

356

258

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Abstract:Optical coherence elastography (OCE), as the use of OCT to perform elastography has come to be known, began in 1998, around ten years after the rest of the field of elastography -the use of imaging to deduce mechanical properties of tissues. After a slow start, the maturation of OCT technology in the early to mid 2000s has underpinned a recent acceleration in the field. With more than 20 papers published in 2015, and more than 25 in 2016, OCE is growing fast, but still small compared to the companion fields of cell mechanics research methods, and medical elastography. In this review, we describe the early developments in OCE, and the factors that led to the current acceleration. Much of our attention is on the key recent advances, with a strong emphasis on future prospects, which are exceptionally bright.

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“…As other imaging techniques, to characterize mechanical parameters of agar or silicon phantoms, Qi et al 21 reported acoustic radiation force optical coherence elastography with several micrometer resolution in imaging and an ultrasound transducer for excitation. However, they have not realized a non-contact impulse excitation against soft materials.…”

Section: Introductionmentioning

confidence: 99%

High spatial and temporal resolution measurement of mechanical properties in hydrogels by non-contact laser excitation

et al. 2016

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Gels have received increased attention as potential materials for biological materials because they can exhibit similar mechanical properties. One obstacle for using gels is that their mechanical properties are significantly altered by defects, such as an inhomogeneous crosslink density distribution. If these defects could be detected and the values and spatial distributions of mechanical properties in the gel could be determined, it would be possible to apply gels for several fields. To achieve the high spatial and temporal resolution measurement of mechanical properties in hydrogels, in our method, a conventional contact excitation device is replaced with a non-contact excitation using laser ablation for the input and magnetic resonance elastography to measure stress waves is replaced with the Schlieren method with a high-speed camera. Magnetic resonance elastography is a local measurement technique, and consequently, requires a lot of time to characterize a sample, as well as does not have sufficient spatial resolution to obtain a broad range of elasticity coefficients of gels. We use laser ablation to apply non-contact impulse excitations to gels to generate stress waves inside them. We can determine mechanical properties of gels using the stress waves’ propagation velocity.

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Resonant acoustic radiation force optical coherence elastography

Cited by 57 publications

References 15 publications

Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens

Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

High spatial and temporal resolution measurement of mechanical properties in hydrogels by non-contact laser excitation

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