Resonancia magnética cardiovascular en la práctica cardiológica: una guía concisa para la adquisición de imágenes y la interpretación clínica

Valbuena-López, Silvia; Hinojar, Rocío; Püntmann, Valentina O.

doi:10.1016/j.recesp.2015.11.012

Cited by 37 publications

(8 citation statements)

References 41 publications

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“…Thus, in this preclinical investigation, we used CMR for morphological and functional evaluation of the heart. This imaging technique is widely recommended for the assessment of IS and cardiac function [40][41][42][43][44] and offers a variety of parameters potentially suited as surrogate end-points in clinical studies 45 . In clinical research the most relevant parameter for assessing heart function is LVEF 42,43 .…”

Section: Discussionmentioning

confidence: 99%

Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model

Báez-Díaz

Blanco-Blázquez

Sánchez-Margallo

et al. 2020

Sci Rep

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Insulin-like growth factor-1 (IGF-1) has demonstrated beneficial effects after myocardial infarction (MI). Microencapsulation of IGF-1 could potentially improve results. We aimed to test the effect of an intracoronary (IC) infusion of microencapsulated IGF-1 in a swine acute MI model. For that purpose IC injection of a 10 ml solution of 5 × 10 6 IGF-1 loaded microspheres (MSPs) (n = 8, IGF-1 MSPs), 5 × 10 6 unloaded MSPs (n = 9; MSPs) or saline (n = 7; CON) was performed 48 hours post-MI. Left ventricular ejection fraction (LVEF), indexed ventricular volumes and infarct size (IS) were determined by cardiac magnetic resonance at pre-injection and 10 weeks. Animals were euthanized at 10 weeks, and myocardial fibrosis and vascular density were analysed. End-study LVEF was significantly greater in IGF-1 MSPs compared to MSPs and CON, while ventricular volumes exhibited no significant differences between groups. IS decreased over time in all groups. Collagen volume fraction on the infarct area was significantly reduced in IGF-1 MSPs compared to CON and MSPs. Vascular density analysis of infarct and border zones showed no significant differences between groups. In conclusion, the IC injection of 5 × 10 6 IGF-1 loaded MSPs in a porcine acute MI model successfully improves cardiac function and limits myocardial fibrosis, which could be clinically relevant.Cardiovascular diseases, especially ischemic heart disease, are the leading cause of mortality worldwide accounting for almost 4 million deaths a year in Europe 1,2 . Conventional treatments such as angioplasty and coronary stenting have contributed to reduce early mortality after an acute myocardial infarction (MI) 3 . However, such therapies are only palliative and do not recover the damaged myocardial tissue 4 , so that these diseases still represent a major unmet medical need.In the last two decades stem cell therapy has become a promising treatment option for ischemic cardiomyopathy 5 . As a result, the administration of various cell types has been proposed to address this problem but has shown only moderate improvements in cardiac function 6 .Recently, several studies suggest that the beneficial effect of stem cells does not lie in their multiplication, but in their paracrine actions 7 . Based on this insight, current research directions in regenerative cardiology are moving to a cell-less approach, since it is known now that stem cells are able to secrete combinations of biomolecules that modulate the composition of the damaged cardiac environment contributing to functional tissue repair by stimulating the migration, proliferation and survival of endogenous cardiac progenitor cells (eCSCs) 8,9 , as well as attenuating fibrosis and modulating inflammation 10,11 .Among the secreted substances, there are different cytokines, extracellular vesicles and growth factors including insulin-like growth factor-1 (IGF-1), hepatocyte growth factor (HGF), angiopoietin 2 or vascular endothelial 1

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Section: Discussionmentioning

confidence: 99%

Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model

Báez-Díaz

Blanco-Blázquez

Sánchez-Margallo

et al. 2020

Sci Rep

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“…Right ventricular function. 26,27 It is the gold standard for the study of right cavities so it should be considered as the preferred option in patients with HF and significant Right Ventricle involving. c.4.…”

Section: Noninvasive Cardiovascular Imagingmentioning

confidence: 99%

“…Diastolic function. 27 In special cases of patients with heart failure with preserved ejection fraction (HF-pEF), Cardiac MRI is useful as part 26,27 Due to its accuracy, it is the first choice method for the study of complex congenital heart disease where an echocardiographic study is insufficient. c.6.…”

Section: Noninvasive Cardiovascular Imagingmentioning

confidence: 99%

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Primera declaración Mexicana en materia de Insuficiencia Cardiaca

Serrano¹,

López²,

Mendoza³

et al. 2021

Cardiovasc Metab Sci

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“…From the clinical point of view, in recent decades, the use of waveform imaging has become more widespread. One of the fields where its use is growing the most is cardiology, especially diagnosis by computed tomography (CT) and magnetic resonance imaging (MRI), mainly because they are non-invasive tests that provide versatility and the capacity to produce detailed images of the heart, which favors precision in diagnosis; they are also currently the reference tests for the study of the morphology and functioning of the heart [4,5].…”

Section: Introductionmentioning

confidence: 99%

Cost Analysis of Magnetic Resonance Imaging and Computed Tomography in Cardiology: A Case Study of a University Hospital Complex in the Euro Region

Reyes-Santias,

García-García,

Aibar-Guzmán

et al. 2023

Healthcare

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Introduction: In recent years, several hospitals have incorporated MRI equipment managed directly by their cardiology departments. The aim of our work is to determine the total cost per test of both CT and MRI in the setting of a Cardiology Department of a tertiary hospital. Materials and Methods: The process followed for estimating the costs of CT and MRI tests consists of three phases: (1) Identification of the phases of the testing process; (2) Identification of the resources consumed in carrying out the tests; (3) Quantification and assessment of inputs. Results: MRI involves higher personnel (EUR 66.03 vs. EUR 49.17) and equipment (EUR 89.98 vs. EUR 33.73) costs, while CT consumes higher expenditures in consumables (EUR 93.28 vs. EUR 22.95) and overheads (EUR 1.64 vs. EUR 1.55). The total cost of performing each test is higher in MRI (EUR 180.60 vs. EUR 177.73). Conclusions: We can conclude that the unit cost of each CT and MRI performed in that unit are EUR 177.73 and EUR 180.60, respectively, attributable to consumables in the case of CT and to amortization of equipment and staff time in the case of MRI.

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Resonancia magnética cardiovascular en la práctica cardiológica: una guía concisa para la adquisición de imágenes y la interpretación clínica

Cited by 37 publications

References 41 publications

Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model

Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model

Primera declaración Mexicana en materia de Insuficiencia Cardiaca

Cost Analysis of Magnetic Resonance Imaging and Computed Tomography in Cardiology: A Case Study of a University Hospital Complex in the Euro Region

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