Resonance Raman and Raman Spectroscopy for Breast Cancer Detection

Liu, C.-H.; Zhou, Yan; Sun, Yi; Li, J. Y.; Zhou, Lixin; Boydston‐White, Susie; Masilamani, V.; Zhu, Ke; Pu, Yang; Alfano, R. R.

doi:10.7785/tcrt.2012.500325

Cited by 99 publications

(62 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2 and Table 1. 12,20,21,24,39 The significant RR molecular markers in different status lesions revealed good agreement between prior work and this study. 11,16 II.…”

Section: Resultssupporting

confidence: 79%

“…[17][18][19] In our previous studies using 532-nm excitation for RR on human brain, breast, gynecological, gastrointestinal, and atherosclerotic abdominal aortic tissues studies, 16,[20][21][22][23][24] the RR spectra in vitro exhibited native molecular signatures that could be used as optical histopathological criteria to distinguish normal from abnormal tissues. The 532-nm wavelength is a newly important finding for tissue to generate extraordinarily large Raman signals that are useful for quasireal-time measurements.…”

Section: Introductionmentioning

confidence: 99%

“…These methods yielded a diagnostic sensitivity of 90.9% and a specificity of 100%. [20][21] Reports detailing the use of the RR technique for studying cardiovascular disease are very limited. One early report on RR scattering spectra in human breast and lung tissues was published by Alfano et al 25 for the first time.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vulnerable atherosclerotic plaque detection by resonance Raman spectroscopy

et al. 2016

View full text Add to dashboard Cite

Abstract. A clear correlation has been observed between the resonance Raman (RR) spectra of plaques in the aortic tunica intimal wall of a human corpse and three states of plaque evolution: fibrolipid plaques, calcified and ossified plaques, and vulnerable atherosclerotic plaques (VPs). These three states of atherosclerotic plaque lesions demonstrated unique RR molecular fingerprints from key molecules, rendering their spectra unique with respect to one another. The vibrational modes of lipids, cholesterol, carotenoids, tryptophan and heme proteins, the amide I, II, III bands, and methyl/methylene groups from the intrinsic atherosclerotic VPs in tissues were studied. The salient outcome of the investigation was demonstrating the correlation between RR measurements of VPs and the thickness measurements of fibrous caps on VPs using standard histopathology methods, an important metric in evaluating the stability of a VP. The RR results show that VPs undergo a structural change when their caps thin to 66 μm, very close to the 65-μm empirical medical definition of a thin cap fibroatheroma plaque, the most unstable type of VP.

show abstract

“…2 and Table 1. 12,20,21,24,39 The significant RR molecular markers in different status lesions revealed good agreement between prior work and this study. 11,16 II.…”

Section: Resultssupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vulnerable atherosclerotic plaque detection by resonance Raman spectroscopy

et al. 2016

View full text Add to dashboard Cite

show abstract

“…32 As a result of the sample degradation and photo damage at UV excitation, Raman spectroscopy with NIR laser light excitation is particularly attractive with an additional advantage of deeper penetration into the tissue. 33 Therefore, NIR Raman spectroscopy has been studied for the detection of malignant lesions in a number of organs, including the cervix, 34 skin, 35 breast, 36 and kidney. 37 High diagnostic accuracies have been achieved for discriminating early gastric cancer (GC; 93%) and CRC (93.2%) from normal tissues.…”

Section: Raman Spectroscopymentioning

confidence: 99%

Biomedical optical spectroscopy for the early diagnosis of gastrointestinal neoplasms

2017

View full text Add to dashboard Cite

Gastrointestinal cancer is a leading contributor to cancer-related morbidity and mortality worldwide. Early diagnosis currently plays a key role in the prognosis of patients with gastrointestinal cancer. Despite the advances in endoscopy over the last decades, missing lesions, undersampling and incorrect sampling in biopsies, as well as invasion still result in a poor diagnostic rate of early gastrointestinal cancers. Accordingly, there is a pressing need to develop noninvasive methods for the early detection of gastrointestinal cancers. Biomedical optical spectroscopy, including infrared spectroscopy, Raman spectroscopy, diffuse scattering spectroscopy and autofluorescence, is capable of providing structural and chemical information about biological specimens with the advantages of non-destruction, non-invasion and reagent-free and waste-free analysis and has thus been widely investigated for the diagnosis of oesophageal, gastric and colorectal cancers. This review will introduce the advances of biomedical optical spectroscopy techniques, highlight their applications for the early detection of gastrointestinal cancers and discuss their limitations.

show abstract

“…The Raman peaks occur at 827, 1078, 1305, 1447, 1653, and 1747 cm -1 in normal tissues, and at 815, 1078, 1243, 1308, 1453, 1663, and 1750 cm -1 in cancerous tissues. The assignments of the individual peaks are listed in Table 1 [10].…”

mentioning

confidence: 99%

Discrimination of Breast Cancer from Normal Tissue with Raman Spectroscopy and Chemometrics

Wang

Liu

et al. 2015

J Appl Spectrosc

View full text Add to dashboard Cite

Conventional Raman spectra of normal and cancerous breast tissues were acquired at an excitation wavelength of 785 nm and subjected to a discrimination analysis. First the spectra were pretreated with wavelet transform and polynomial fi tting; next, cancerous tissue was identifi ed by applying an adaptive local hyperplane K-nearest neighbor (ALHK) method to the pretreated spectra. The best discrimination accuracy of the ALHK method was 93.2%. In summary, normal and cancerous breast tissue were accurately distinguished by a miniature laser Raman spectrometer and the chemometrics method (ALHK), which might prove to be a portable and accessible diagnostic system.

show abstract

Resonance Raman and Raman Spectroscopy for Breast Cancer Detection

Cited by 99 publications

References 47 publications

Vulnerable atherosclerotic plaque detection by resonance Raman spectroscopy

Vulnerable atherosclerotic plaque detection by resonance Raman spectroscopy

Biomedical optical spectroscopy for the early diagnosis of gastrointestinal neoplasms

Discrimination of Breast Cancer from Normal Tissue with Raman Spectroscopy and Chemometrics

Contact Info

Product

Resources

About