“…This is evidenced in Fig. 5. (c) When the duration of an individual chemotherapy administration is greater than roughly two thirds of the S-phase duration, then use of resonance ideas (Dibrov et al, 1985;Agur et al, 1988Agur et al, , 1991Agur et al, , 1992Webb, 1990;Cojocaru and Agur, 1992;Webb, 1992a,b;Agur and Dvir, 1994;Ubezio et al, 1994;Webb and Johnson, 1996;Agur, 1998;Dibrov, 1998;Shochat et al, 1999;Anderson and Mackey, 2001) typically leads to an optimal or near optimal protocol given low values for the variance of the tumour cell cycle time. However, such resonance based timings are clearly inappropriate for larger, but nonetheless physiologically reasonable, values for the variance of the tumour cell cycle time, especially given larger rest phase durations.…”