Resolvins resolve to heal mucosal wounds

Resolvins: The resolving mediators divulged

“… The selective blocking of thromboxane-stimulated platelet aggregation and adenosine diphosphate (ADP) with RvE1 has been noted in human-rich plasma which was concentration-dependent [27] .  RvE1 has also shown to possess regulatory actions by demonstrating the reduction of ADP-stimulated Pselectin surface mobilization [28] .  RvE2 has been shown to maintain homeostasis by downregulating the expression of leukocytes in human whole blood [29] .…”

E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutrition

“… Peritonitis [ 21 , 72 , 77 , 78 , 80 ], air pouch [ 21 ], CLP/sepsis [ 106 ], bacterial [ 101 ], I/R injury [ 107 ], diabetes [ 108 ], obesity [ 112 ], colitis [ 99 , 109 , 110 ]; lung inflammation [ 111 ], kidney injury [ 199 ], depression Alzheimer’s [ 200 ], atherosclerosis [ 113 , 201 ], bone[ 81 ], reduces tumor growth [ 114 ], Dermatitis [ 115 ], Candida albicans [ 116 ], pain [ 118 ], and reduces herpes [ 117 ]. Plasma [ 119 ] Nano-delivery of RvE1 repairs gastrointestinal injury and activates wound healing [ 110 , 202 ] Plasma from arthritis patients [ 46 ] Reduces pro-inflammatory cytokines [ 101 ]. Arthritic synovial fluid exudates [ 46 ] Enhances MΦ phagocytosis & efferocytosis [ 77 , 80 ].…”

Hypoxia‐inducible factor‐dependent induction of myeloid‐derived netrin‐1 attenuates natural killer cell infiltration during endotoxin‐induced lung injury

“…Indeed, endogenous mechanisms and immune‐modulators are programed to limit inflammation and restore tissue homeostasis 16‐23 . Such mechanisms include negative feedback pathways that serve to dampen inflammation and active stimulation by pro‐resolution mediators that coordinate the termination of inflammation 21,24‐30 . Myeloid cells, such as macrophages and neutrophils, are a crucial part of innate immunity and key drivers of the initiation and resolution of inflammation.…”

“…[16][17][18][19][20][21][22][23] Such mechanisms include negative feedback pathways that serve to dampen inflammation and active stimulation by pro-resolution mediators that coordinate the termination of inflammation. 21,[24][25][26][27][28][29][30] Myeloid cells, such as macrophages and neutrophils, are a crucial part of innate immunity and key drivers of the initiation and resolution of inflammation. For example, during lung inflammation, monocytes are recruited to the inflamed air space to differentiate into macrophages secreting cytokines that act locally to stimulate chemotaxis and activate neutrophils.…”