Resolvins and protectins in the termination program of acute inflammation

Ariel, Amiram; Serhan, Charles N.

doi:10.1016/j.it.2007.02.007

Cited by 330 publications

(223 citation statements)

References 71 publications

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“…Myelin, the insulating layer of nerve sheaths, contains plasmalogens; absence of the ether phospholipid is associated with progressive neurological impairment [9] . Docosahexaenoic acids, peroxisomally produced omega-3 fatty acids, are the pivotal precursors of resolvins ("resolution-phase interaction products"), maresins ("macrophage mediator in resolving inflammation"), and protectins (formerly called "neuroprotectins") [10][11][12] . These molecules possess potent anti-inflammatory, inflammatory resolving, and immunoregulatory activities.…”

Section: Synthesismentioning

confidence: 99%

Peroxisomes, oxidative stress, and inflammation

Terlecky

Terlecky²,

Giordano³

2012

WJBC

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Peroxisomes are intracellular organelles mediating a wide variety of biosynthetic and biodegradative reactions. Included among these are the metabolism of hydrogen peroxide and other reactive species, molecules whose levels help define the oxidative state of cells. Loss of oxidative equilibrium in cells of tissues and organs potentiates inflammatory responses which can ultimately trigger human disease. The goal of this article is to review evidence for connections between peroxisome function, oxidative stress, and inflammation in the context of human health and degenerative disease. Dysregulated points in this nexus are identified and potential remedial approaches are presented.

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Section: Synthesismentioning

confidence: 99%

Peroxisomes, oxidative stress, and inflammation

Terlecky

Terlecky²,

Giordano³

2012

WJBC

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“…Importantly, resolvin synthesis is increased in the blood or peripheral tissues of both humans and laboratory rodent with enriched levels of EPA and DHA by dietary means (Calder, 2015). The anti-inflammatory activity of these compounds is linked to the inhibition of the synthesis of proinflammatory cytokines such as IL-1β and TNFα and the inhibition of trans-endothelial migration of neutrophils into tissues, preventing the infiltration of these cells in inflamed tissues therefore protecting from excessive inflammation (Ariel and Serhan, 2007;Calder, 2015). Some of the biological activities of resolvins are mediated by specific G-protein coupled receptors.…”

Section: N-pufas Neuroinflammation and Cognitive Disordersmentioning

confidence: 99%

N-3 PUFAs and neuroinflammatory processes in cognitive disorders

Leyrolle

Layé

Nadjar

2016

OCL

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-With the ageing population and increased cases of neurodegenerative diseases, there is a crucial need for the development of new nutritional approaches to prevent and delay the onset of cognitive decline. Neuroinflammatory processes contribute to neuronal damage that underpins neurodegenerative disorders. Growing evidence sheds light on the use of dietary n-3 long chain polyunsaturated fatty acids to improve cognitive performances and reduce the neuroinflammatory responses occurring with age and neurodegenerative pathologies. This review will summarise the most recent information related to the impact and mechanisms underlying the neuroinflammatory processes in cognitive disorders. We will also discuss the mechanisms underlying n-3 polyunsaturated fatty acids effect on neuroinflammation and memory decline.Keywords: Neuroinflammation / microglia / n-3 polyunsaturated fatty acids / cognitive disorders / Alzheimer disease Résumé -Acides gras polyinsaturés de la famille des oméga 3, processus neuroinflammatoires et troubles cognitifs. Le développement d'approches nutritionnelles pertinentes pour prévenir et retarder l'apparition du déclin cognitif est un enjeu important, compte tenu du vieillissement de la population et de l'augmentation de l'incidence des maladies neurodégénératives. Les processus neuro-inflammatoires contribuent aux mécanismes neuropathologiques impliqués dans les troubles neurodégénératifs et de la cognition. Des données récentes indiquent l'importance des acides gras polyinsaturés n-3 alimentaires dans le maintien des performances mnésiques et la régulation de la neuroinflammation liée à l'âge ou à la maladie d'Alzheimer. Dans cette revue, seront présentées des données récentes sur les liens existants entre le statut nutritionnel en acides gras polyinsaturés n-3, les processus neuro-inflammatoires et les troubles cognitifs associés, ainsi que les mécanismes qui pourraient être impliqués dans les effets protecteurs de ces acides gras.

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“…Endocannabinoids can also be categorized in this class, since the hallmark endocannabinoid, 2-arachidonoyl-glycerol, has a glycerol backbone and since endocannabinoid receptors cluster in close proximity to lysophospholipid receptors on the phylogenetic tree [11]. Class 3 represents newly identified anti-inflammatory lipid mediators derived from ω-3 polyunsaturated fatty acids (PuFas), such as resolvins [derived from eicosapentaenoic acid (EPa)] and protectins [derived from docosahexaenoic acid (DHa)] [2], whose biosynthetic enzymes and receptors are not yet fully understood. In addition, given the recent findings of a few unique GPCrs that recognize medium-to longchain fatty acids [75], it is conceivable that some nutrient lipids abundantly present in the circulation or tissues could exhibit lipid mediator-like actions and be regarded as another class of lipid mediators.…”

Section: Lipid Mediatorsmentioning

confidence: 99%

“…Class 3: ω-3 PUFA derivatives recent advances in lipidomic techniques have allowed the identification of new class of lipid mediators derived from ω-3 PuFa (e.g., EPa and DHa) [2]. Pioneered by Serhan and Bazan, these ω-3 lipid mediators such as resolvins, protectins and maresins, as well as lipoxins derived from ω-6 aa, have recently attracted considerable attention as critical mediators of the resolution of inflammation [6,68].…”

Section: Class 2: Lysophosholipids and Their Derivativesmentioning

confidence: 99%

“…in this article, i will provide an overview of the classification and roles of various lipid mediators, such as eicosanoids, lysophospholipids, sphingolipids, and endocannabinoids. in the latter part, i will focus on a particular enzyme that produces the most intensively studied lipid mediator, PGE 2 . On the bases of cell biological and clinical studies, together with recent analyses of mice with manipulation of its gene, PGE 2 synthase (PGES) now attracts much attention as a potential target for a new class of anti-inflammatory, analgesic and anticancer drugs which are currently being developed.…”

Section: Introductionmentioning

confidence: 99%

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Lipid Mediators in Life Science

2011

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"Lipid mediators" represent a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. They are exported extracellularly, bind to their cognate G protein-coupled receptors (GPCRs) to transmit signals to target cells, and are then sequestered rapidly through specific enzymatic or non-enzymatic processes. Because of these properties, lipid mediators can be regarded as local hormones or autacoids. Unlike proteins, whose information can be readily obtained from the genome, we cannot directly read out the information of lipids from the genome since they are not genome-encoded. However, we can indirectly follow up the dynamics and functions of lipid mediators by manipulating the genes encoding a particular set of proteins that are essential for their biosynthesis (enzymes), transport (transporters), and signal transduction (receptors). Lipid mediators are involved in many physiological processes, and their dysregulations have been often linked to various diseases such as inflammation, infertility, atherosclerosis, ischemia, metabolic syndrome, and cancer. In this article, I will give an overview of the basic knowledge of various lipid mediators, and then provide an example of how research using mice, gene-manipulated for a lipid mediator-biosynthetic enzyme, contributes to life science and clinical applications.

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Resolvins and protectins in the termination program of acute inflammation

Cited by 330 publications

References 71 publications

Peroxisomes, oxidative stress, and inflammation

Peroxisomes, oxidative stress, and inflammation

N-3 PUFAs and neuroinflammatory processes in cognitive disorders

Lipid Mediators in Life Science

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