Resolving sulfation PTMs on a plant peptide hormone using nanopore sequencing
Xiuqi Chen,
Jasper W. van de Sande,
Justas Ritmejeris
et al.
Abstract:Peptide phytohormones are decorated with post-translational modifications (PTMs) that are crucial for receptor recognition. Tyrosine sulfation on these hormones is essential for plant growth and development. Measuring the occurrence and position of sulfotyrosine is, however, compromised by major technical challenges during isolation and detection. We recently introduced a nanopore peptide sequencing method that sensitively detects PTMs at the single-molecule level. By translocating PTM variants of the plant pe… Show more
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