Resolving arterial phase and temporal enhancement characteristics in DCE MRM at high spatial resolution with TWIST acquisition

Herrmann, Karl‐Heinz; Baltzer, Pascal; Dietzel, Matthias; Krumbein, Ines; Geppert, Christian; Kaiser, Werner A.; Reichenbach, Jürgen R.

doi:10.1002/jmri.22689

Cited by 45 publications

(26 citation statements)

References 18 publications

(34 reference statements)

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“…The sequence parameters were chosen on the basis of typical MR protocols used in clinic practice for breast [19]. The fixed parameters were: TR/TE = 3.08/1.18 ms, acquisition matrix 320 Â 290, slice thickness 2 mm, gap 0 mm, pixel spacing 1:09 Â 1:09 mm 2 .…”

Section: Twist Acquisitionsmentioning

confidence: 99%

“…Previous works [19,20] has demonstrated the clinical potential of TWIST acquisitions to provide very high temporal resolution in patients undergoing routine breast DCE-MRI, while still maintaining sufficient spatial resolution and image quality. They showed that TWIST acquisitions proved very robust and offer high flexibility in protocol timing.…”

Section: Introductionmentioning

confidence: 98%

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Accuracy of Contrast Agent Quantification in MRI: A Comparison Between Two k-space Sampling Schemes

2015

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Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) plays an important role in many applications, such as perfusion imaging in oncology. Several aspects of data acquisition should be taken into account when developing protocols for DCE MRI both to facilitate integration of results from multiple institutions and to ensure that the data reflect the underlying physiology as accurately as possible.In this study we focused on the trade-off between accurate contrast agent (CA) quantification ad temporal resolution. The commonly used spoiled gradient-echo k-space scheme known as Fast Low Angle SHot (FLASH) can suffer from low temporal resolution if a large field of view must be scanned. Recently, a k-space under-sampling and data-sharing method known as Time-resolved angiography With Stochastic Trajectories (TWIST) has been proposed to obtain high temporal resolution without sacrificing the spatial resolution. However, the losses in CA quantification have not been analyzed yet.The aim of this study was to evaluate the accuracy of TWIST CA quantification with respect to FLASH.Seven vials containing different Gd-DTPA solutions were prepared. Images were acquired using breast coils and several combinations of the different parameters of the two schemes analyzed. Quantification accuracy has been evaluated in terms of relative error and standard deviation. Also the repeatability for both sequence was evaluated on ten measures.The accuracy of CA quantification with both sequences depends on the specific amount of Gd-DTPA present in the prepared solutions.However, our results show that FLASH and TWIST give comparable accurac

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Section: Twist Acquisitionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Accuracy of Contrast Agent Quantification in MRI: A Comparison Between Two k-space Sampling Schemes

2015

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“…In optical mammography, analysis of early and very early contrast enhancement is of interest for the following reasons: 1) Despite ongoing technical developments in MR imaging, the temporal resolution achieved is still lower than that of optical techniques [88,89]. 2) The contrast agent ICG differs from gadolinium-DTPA in terms of distribution in different compartments as ICG acts as blood-pool contrast due to strong protein binding ; this difference results from the strong protein binding of ICG, which makes ICG a bloodpool contrast agent [90].…”

Section: Indocyanine Green As An Contrast Agent To Enhance Absorptionmentioning

confidence: 99%

Near‐infrared imaging of breast cancer using optical contrast agents

Poellinger

2012

Journal of Biophotonics

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Breast cancer is the most common malignancy in women worldwide and the second leading cause of cancer death. On the basis of three studies performed by our group, this article reviews the current status of optical breast imaging using extrinsic contrast agents. To date, only two contrast agents have been applied in human studies, indocyanine green (ICG) and omocianine. Both contrast media were used for absorption and fluorescence imaging. Generally speaking, malignant breast lesions exhibited higher absorption contrast as well as higher fluorescence contrast compared to benign lesions or non‐diseased breast tissue. Some groups consider early enhancement characteristics helpful for differentiation between malignant and benign lesions. Late fluorescence ICG imaging – capitalizing on the extravasation of the dye through the wall of tumorous vessels – seems to be a promising technique to distinguish malignant from benign breast lesions. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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“…Some of these advancements, such as parallel imaging (20-22), are widely accepted and used in clinical breast MRI; however, other data acquisition acceleration techniques, such as undersampled radial imaging (23, 24) and k-t segmentation schemes (25, 26), are less well-established. The more randomized k-t sampling approaches that have been introduced in recent years were proposed to help reduce temporal blurring and coherent artifacts (26, 27) as compared with earlier methods that did not use random sampling and updated discrete, non-intermingled k-space regions.…”

Section: Introductionmentioning

confidence: 99%

Novel High Spatiotemporal Resolution Versus Standard-of-Care Dynamic Contrast-Enhanced Breast MRI

Morrison¹,

Bancroft

DeMartini³

et al. 2017

Invest Radiol

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Objective Currently, dynamic contrast-enhanced breast MRI prioritizes spatial resolution over temporal resolution given the limitations of acquisition techniques. The purpose of our intra-patient study was to assess the ability of a novel high spatial and high temporal resolution DCE breast MRI method to maintain image quality compared to the clinical standard-of-care (SOC) MRI. Materials and Methods Thirty patients, each demonstrating a focal area of enhancement (29 benign, 1 cancer) on their SOC MRI consented to undergo a research DCE breast MRI on a second date. For the research DCE MRI, a method (DISCO) employing pseudo-random k-space sampling, view sharing reconstruction, two-point Dixon fat-water separation, and parallel imaging was used to produce images with an effective temporal resolution six times faster than the SOC MRI (27 seconds versus 168 seconds, respectively). Both the SOC and DISCO MR images were acquired with matching spatial resolutions of 0.8 × 0.8 × 1.6 mm3. Image quality (distortion/artifacts, resolution, fat suppression, lesion conspicuity, perceived SNR, and overall image quality) was scored by three radiologists in a blinded reader study. Results Differences in image quality scores between the DISCO and SOC images were all less than 0.8 on a 10-point scale, and both methods were assessed as providing diagnostic image quality in all cases. DISCO images with the same high spatial resolution, but six times the effective temporal resolution as the SOC MR images were produced, yielding 20 post-contrast time-points with DISCO compared with three for the SOC MRI, over the same total time interval. Conclusions DISCO provided comparable image quality compared to the SOC MRI, while also providing six-times faster effective temporal resolution and the same high spatial resolution.

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Resolving arterial phase and temporal enhancement characteristics in DCE MRM at high spatial resolution with TWIST acquisition

Cited by 45 publications

References 18 publications

Accuracy of Contrast Agent Quantification in MRI: A Comparison Between Two k-space Sampling Schemes

Accuracy of Contrast Agent Quantification in MRI: A Comparison Between Two k-space Sampling Schemes

Near‐infrared imaging of breast cancer using optical contrast agents

Novel High Spatiotemporal Resolution Versus Standard-of-Care Dynamic Contrast-Enhanced Breast MRI

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