Abstract:Introduction: Vascular aging is associated with endothelial cell senescence, favoring low-grade inflammation, endothelial dysfunction, and cardiovascular diseases. Cell senescence arises from a wide variety of endogenous and exogenous stressors including some anticancer agents such as doxorubicin. Recently, doxorubicin was linked to the innate immunity component NLRP3 inflammasome which is implicated in many vascular inflammatory disorders. There is a need for therapeutic tools to help cancer patients who have… Show more
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