Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension

Olivares-Silva, Francisco; Gregorio, Nicole De; Espitia-Corredor, Jenaro; Espinoza, Claudio; Vivar, Raúl; Schwartz, David A.; Osorio, José Miguel; Lavandero, Sergio; Peiró, Concepción; Sánchez‐Ferrer, Carlos F.; Díaz‐Araya, Guillermo

doi:10.1016/j.bbadis.2021.166241

Cited by 16 publications

(9 citation statements)

References 49 publications

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“…In the resting state, the binary logistic regression between groups showed that the effects of 11 indexes were large. interventricular septum and posterior wall thickness thickening are common symptoms in patients with hypertension [27] [28]. In hypertrophic myocardium, glucose utilization and glycolysis process are enhanced, while aerobic oxidation process was relatively weakened, namely "glycolysisuncoupling of glucose oxidation" [29] [30], which led to the upregulation of D-xylulose, D-fructose and oxyadipic acid.…”

Section: Discussionmentioning

confidence: 99%

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Zhang¹,

Xu²,

Gao³

et al. 2023

Preprint

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Background Hypertension is a kind of clinical syndrome, characterized by the increase of systemic arterial pressure. There is a lack of identifiable triggers and predictors of hypertensive disease in response to treatment at rest and during exercise. In this study, a mathematical model was used to screen and compare the indicators and related changes at rest and during exercise between normotensive and hypertensive individuals. Methods Blood pressure and ultrasound-related indicators, blood biochemical indicators and metabolic compounds were collected and logistic regression model and Principal component analysis (PCA) were used to explore the differences of indexes at rest and in different exercise states in healthy and hypertensive patients. An indicator change map for hypertension is established. Results The results reveal that hypertension is not only related to oxidative stress, inflammatory reaction and fatty acid oxidation, but also involves various amino acid metabolism. The defined mathematical models and indicators changes during exercise might be helpful for early screening of hypertension and future studies are needed to explore their value on prevention and control of hypertension. Conclusion The research shows that the main regulation indicators at different exercise states differ significantly in the normal group and the hypertensive group. The key indicators of the normal group are blood pressure and ultrasound related indicators, while those of the hypertensive group are metabolites related to lactic acid metabolism, glycolysis, aerobic oxidation and lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Zhang¹,

Xu²,

Gao³

et al. 2023

Preprint

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show abstract

“…Inflammation is a rapid, nonspecific defense response of the body that acts to maintain hemostasis via monitoring and clearing of foreign bodies. This involves coordinating vascular endothelial cells and circulating inflammatory cells and cytokines ( 48 ). Although inflammation has beneficial effects, including eradicating pathogens and protecting organs from damage, imbalanced regulation may cause serious and sustained inflammatory response that can in turn cause progressive tissue injury, organ dysfunction, and fibrosis, and even systemic inflammatory response syndrome.…”

Section: Inflammation In Hypertensionmentioning

confidence: 99%

“…Briefly, a wide range of DAMPs or PAMPs stimulate NLRP3 activation by inducing ion transporting (e.g., K + efflux and Ca 2+ influx) and lysosomal leakage. The activated NLRP3 inflammasome then triggers caspases to induce cleavage of inactive proinflammatory cytokine precursors, such as pro-IL-1β, pro-IL-18, and pro-IL-37 ( Figure 1 ) ( 48 ). Numerous studies show that activated NLRP3 inflammasomes are tightly associated with many chronic inflammatory and metabolic diseases, such as ischemic heart diseases and diabetes mellitus, stroke, atherosclerosis, and hypertension ( 56 – 59 ).…”

Section: Inflammation In Hypertensionmentioning

confidence: 99%

Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets

et al. 2023

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Hypertension is regarded as the most prominent risk factor for cardiovascular diseases, which have become a primary cause of death, and recent research has demonstrated that chronic inflammation is involved in the pathogenesis of hypertension. Both innate and adaptive immunity are now known to promote the elevation of blood pressure by triggering vascular inflammation and microvascular remodeling. For example, as an important part of innate immune system, classically activated macrophages (M1), neutrophils, and dendritic cells contribute to hypertension by secreting inflammatory cy3tokines. In particular, interferon-gamma (IFN-γ) and interleukin-17 (IL-17) produced by activated T lymphocytes contribute to hypertension by inducing oxidative stress injury and endothelial dysfunction. However, the regulatory T cells and alternatively activated macrophages (M2) may have a protective role in hypertension. Although inflammation is related to hypertension, the exact mechanisms are complex and unclear. The present review aims to reveal the roles of inflammation, immunity, and oxidative stress in the initiation and evolution of hypertension. We envisage that the review will strengthen public understanding of the pathophysiological mechanisms of hypertension and may provide new insights and potential therapeutic strategies for hypertension.

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“…Although the direct relationship between MaR1 and hypertension has not been experimentally tested, by comparing the serum levels of lipoxin and Resolvins in hypertension and normotension patients, Yücel et al found that the lipoxin A4 (LXA4), RvD1 and Resolvin E1 (RvE1) levels were negatively correlated with systolic blood pressure and total cholesterol levels, implying that reduced SPMs may serve as indicators of the development of hypertension ( 44 ). Indeed, RvD1, which is also derived from DHA, had shown protective potential in angiotensin II induced hypertension and cardiac remodeling ( 45 ). Resolvins also showed potential to combat pulmonary arterial hypertension and inhibit pulmonary vessel constriction ( 46 , 47 ).…”

Section: Mar1 and Hypertensive Cardiovascular Diseasementioning

confidence: 99%

Protective Potential of Maresins in Cardiovascular Diseases

Liu

2022

Front. Cardiovasc. Med.

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Cardiovascular diseases are the leading causes of global mortality. Growing evidence suggests that unresolved inflammation contributes to the chronicity, progression and morbidity of many cardiovascular diseases, thus emphasizing the urgent need to illuminate the mechanisms controlling inflammation and its resolution, for the sake of new effective therapeutic options. Macrophage mediators in resolving inflammation (Maresins) are a family of specialized pro-resolving lipid mediators (SPMs) derived from the ω-3 fatty acid docosahexaenoic acid (DHA). Studies have indicated that Maresins play critical role in initiating the pro-resolving functions of phagocytes, decreasing the magnitude of the overall inflammatory response, and thereby protecting against inflammation-related disorders. In this review, we summarize the detailed actions and the therapeutic potential of Maresins, with a particular emphasis on Maresin-1 (MaR1), in cardiovascular diseases. We hope this review will lead to new avenues to Maresins-based therapies for inflammation-associated cardiovascular diseases.

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Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension

Cited by 16 publications

References 49 publications

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Divergent indicator changes in different exercise states in non-hypertensive individuals and patients with hypertension

Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets

Protective Potential of Maresins in Cardiovascular Diseases

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