RESOLVE: a randomized, controlled, blinded study of bioabsorbable steroid‐eluting sinus implants for in‐office treatment of recurrent sinonasal polyposis

Han, Joseph K.; Forwith, Keith D.; Smith, Timothy L.; Kern, Robert C.; Brown, William J.; Miller, Steven K.; Ow, Randall A.; Poetker, David M.; Karanfilov, Boris; Matheny, Keith E.; Stambaugh, James W.; Gawlicka, Anna K.

doi:10.1002/alr.21426

Cited by 58 publications

(60 citation statements)

References 25 publications

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“…Additional indications are on the horizon. 1323 Clinical experience with this device is relatively narrow at this point and evidence, though at a high level, is limited to short-term outcomes (Table X- r Harm: Potential for misplacement and local reaction. r Policy Level: The authors could not come to a consensus on the subject of corticosteroid-eluting stents.…”

Section: Xd6 Surgical Principles/techniques: Drug Eluting Packingmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Xd6 Surgical Principles/techniques: Drug Eluting Packingmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

554

888

View full text Add to dashboard Cite

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“…When inserted at the time of sinus surgery, these stents significantly reduced postoperative surgical interventions by 51%, oral corticosteroid use by 40%, and frank nasal polyposis by 46% 79 after 1 month. Given these findings, a longer-lasting variant of Propel ™ is currently being evaluated in a FDA trial with initial results suggesting this stent can significantly improve polyp size and nasal symptoms 3 months following insertion 80 .…”

Section: Treatmentmentioning

confidence: 99%

Chronic Rhinosinusitis with Nasal Polyps

Stevens

Schleimer

Kern

2016

The Journal of Allergy and Clinical Immunology: In Practice

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354

314

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is an important clinical entity diagnosed by the presence of both subjective and objective evidence of chronic sinonasal inflammation. Symptoms include anterior or posterior rhinorrhea, nasal congestion, hyposmia and/or facial pressure or pain that last for greater than 12 weeks duration. Nasal polyps are inflammatory lesions that project into the nasal airway, are typically bilateral, and originate from the ethmoid sinus. Males are more likely to be affected than females but no specific genetic or environmental factors have been strongly linked to the development of this disorder to date. CRSwNP is frequently associated with asthma and allergic rhinitis but the cellular and molecular mechanisms that contribute to the clinical symptoms are not fully understood. Defects in the sinonasal epithelial cell barrier, increased exposure to pathogenic and colonized bacteria, and dysregulation of the host immune system are all thought to play prominent roles in disease pathogenesis. Additional studies are needed to further explore the clinical and pathophysiological features of CRSwNP so that biomarkers can be identified and novel advances can be made to improve the treatment and management of this disease.

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“…With the beneficial development of office-placed bioabsorbable steroid-eluting implants for CRS, the effects of this focally delivered steroid on olfaction are yet to be determined. 52 …”

Section: Postoperative Considerations For Smell Lossmentioning

confidence: 99%