Resolution of ulcerative colitis

Neurath, Markus F.; Leppkes, Moritz

doi:10.1007/s00281-019-00751-6

Cited by 68 publications

(42 citation statements)

References 104 publications

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“…UC manifested as an idiopathic, relapsing and etiologically complicated inflammatory disorder, involving the interaction between environment factors, genetic emotivity, perturbation of immune homeostasis, and dysfunction of intestinal mucosal barrier 5,6,18 . Over the past decades, oral administration of berberine has been demonstrated to exert protective capacity on DSSinduced experimental acute UC, which dominantly attributed to the critical role of berberine in modulating the inflammatory responses from immune cell and epithelial cells, maintaining the intestinal barrier function, and regulating gut microbiota 24,41,42 .…”

Section: Discussionmentioning

confidence: 99%

“…Ulcerative colitis (UC), belonging to one form of inflammatory bowel diseases (IBD), is characterized by severe diarrhea, unintended weight loss, bloody stools, abdominal pain, and fatigue [1][2][3] . Inflammation in UC is dominantly presented in the mucosal and submucosal layer of colon and rectum 4,5 . The pathogenesis of UC is multidimensional and linked to the coactions between genetic susceptibility, immune system imbalance, dysfunction of intestinal barrier, and turbulence of microorganisms 6,7 .…”

Section: Introductionmentioning

confidence: 99%

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Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis

Feng

Chen

et al. 2020

Cell Death Dis

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Ulcerative colitis (UC) is a chronic and etiologically refractory inflammatory gut disorder. Although berberine, an isoquinoline alkaloid, has been revealed to exert protective effects on experimental colitis, the underlying molecular mechanism in chronic intestinal inflammation remains ill-defined. This study was designed to uncover the therapeutic efficacy and immunomodulatory role of berberine in chronic UC. Therapeutic effects of oral administration of berberine were investigated in dextran sodium sulfate (DSS)-induced murine chronic UC and the underlying mechanisms were further identified by si-OSMR transfection in human intestinal stromal cells. Berberine significantly attenuated the experimental symptoms and gut inflammation of chronic UC. Berberine treatment could also maintain the intestinal barrier function and rectify tissue fibrosis. In accordance with infiltrations of antigen-presenting cells (APCs), innate lymphoid cells (ILCs), and activated NK cells in colonic lamina propria, increased expression of OSM and OSMR were observed in the inflamed tissue of chronic UC, which were decreased following berberine treatment. Moreover, berberine inhibited the overactivation of human intestinal stromal cells through OSM-mediated JAK-STAT pathway, which was obviously blocked upon siRNA targeting OSMR. The research provided an infusive mechanism of berberine and illustrated that OSM and OSMR intervention might function as the potential target in chronic UC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis

Feng

Chen

et al. 2020

Cell Death Dis

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“…68 Ulcerative colitis (UC), an idiopathic inflammatory bowel disease, leads to bloody diarrhea and inflammatory alterations mostly in the large intestine, and affecting the colon and rectum. 69 Overproduction of ROS and consequent inflammation of the mucosa are the important causes of tissue injury in UC. 70 Recent studies have found that some peptide hormones may have a healing effect on UC.…”

Section: Intestinal Diseasesmentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, antiinflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.

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“…These changes result in alterations in the luminal microbiota and dysregulation of the intestinal mucosal immune system, leading to the development of UC 7 . Currently, therapies targeting TNF have been relatively successful in treating certain symptoms of UC 8 . However, even with medical therapy, up to 40% of patients do not initially respond to anti-TNF therapy and approximately 30% of patients lose response over time 9 .…”

Section: Introductionmentioning

confidence: 99%

Integrated analysis of DNA methylation and gene expression profiles identified S100A9 as a potential biomarker in ulcerative colitis

Kong

Zhang

et al. 2020

Bioscience Reports

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Ulcerative colitis (UC) is a prevalent relapsing-remitting inflammatory bowel disease whose pathogenetic mechanisms remain elusive. In the present study, colonic biopsies samples from three UC patients treated in the Traditional Chinese Medicine Hospital and three healthy controls were obtained. The genome-wide mRNA and lncRNA expression of the samples were profiled through Agilent gene expression microarray. Moreover, the genome-wide DNA methylation dataset of normal and UC colon tissues was also downloaded from GEO for a collaborative analysis. Differential expression of lncRNA (DELs) and mRNAs (DEMs) in UC samples compared with healthy samples were identified by using limma Bioconductor package. Differentially methylated promoters (DMPs) in UC samples compared with controls were obtained through comparing the average methylation level of CpGs located at promoters by using t-test. Functional enrichment analysis was performed by the DAVID. STRING database was applied to the construction of gene functional interaction network. As a result, 2090 DEMs and 1242 DELs were screened out in UC samples that were closely associated with processes related to complement and coagulation cascades, osteoclast differentiation vaccinia, and hemorrhagic diseases. A total of 90 DEMs and 72 DELs were retained for the construction of functional network for the promoters of their corresponding genes were identified as DMPs. S100A9, HECW2, SOD3 and HIX0114733 showed high interaction degrees in the functional network, and expression of S100A9 was confirmed to be significantly elevated in colon tissues of UC patients compared with that of controls by qRT-PCR that was consistent with gene microarray analysis. These indicate that S100A9 could potentially be used as predictive biomarkers in UC.

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Resolution of ulcerative colitis

Cited by 68 publications

References 104 publications

Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis

Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Integrated analysis of DNA methylation and gene expression profiles identified S100A9 as a potential biomarker in ulcerative colitis

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