Resolution of (R, S)-4-BrMA Catalyzed by Pseudomonas cepacia Lipase in an Organic Phase

Jiang, Bihui; Xie, Rong; Tang, Kewen

doi:10.1007/s10562-022-04157-2

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…The progress has been achieved in the area of chiral resolution employ lipase immobilization on MOF materials. [22][23][24][25][26][27][28][29][30][31] It can be meet the basic requirements of enzyme immobilization.…”

Section: Introductionmentioning

confidence: 99%

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Efficient resolution of 4‐chlormandelic acid enantiomers using lipase@UiO‐67(Zr) zirconium–organic frameworks in organic solvent

2023

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A new biocatalyst PCL@UiO‐67(Zr) was successfully synthesized by immobilized lipases on metal–organic frameworks (MOFs) materials. Compare with free lipases, zirconium foundation organic framework material UiO‐67(Zr) modification on immobilized lipases Pseudomonas cepacia lipase (PCL) great boosts their enantioselectivity in the kinetic resolution racemic 4‐chloro‐mandelic acid (4‐ClMA) on the organic solvent. The acquired bio‐composite PCL@UiO‐67(Zr) was fully characterized by powder X‐ray diffraction (PXRD), Fourier transform infrared (FT‐IR) spectroscopy, N2 adsorption–desorption isotherm and aperture distribution map, and scanning electron microscopy (SEM). The catalytic performance of PCL@UiO‐67(Zr), such as temperature, reaction time, and lipase quantity, were deeply explored. The experiment results showed resolution racemic 4‐ClMA optimum conditions that 20 mmol/L of (R, S)‐4‐chloromandelic acid, 120 mmol/L vinyl acetate, 30‐mg immobilized lipases PCL@UiO‐67(Zr), 2 mL of MTBE, 500 rpm, and under the 55°C reaction 18 h. In this optimum conditions, c and eep could reach up to 47.6% and 98.7%, respectively.

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Section: Introductionmentioning

confidence: 99%

“…In recent years, the development of MOF materials with high surface area and pore volume, pore size can be adjusted, and materials surface can be modified. The progress has been achieved in the area of chiral resolution employ lipase immobilization on MOF materials 22–31 . It can be meet the basic requirements of enzyme immobilization.…”

Section: Introductionmentioning

confidence: 99%