Resolution of Metastatic Subungal Eccrine Porocarcinoma Treated with Intralesional Interleukin-2

Abstract

Eccrine porocarcinoma is a rare aggressive cutaneous malignancy. Complete surgical excision is the standard of care, although there are high rates of local and distant recurrence. We present a unique case of locally recurrent and metastatic subungal porocarcinoma successfully treated with intralesional interleukin-2.

Metastatic porocarcinoma: A case demonstrating objective response to pembrolizumab

“…Mohs surgery remains the gold standard. There are studies highlighting the efficacy of local treatments at an early stage, such as the application of imiquimod and maxacalcitol (a vitamin D derivative) 4 or the use of intralesional interleukin 2 5 or photodynamic therapy. 6 …”

Cutaneous Breast Cancer Metastasis Is Effectively Treated With Intralesional Interleukin-2 and Imiquimod: A Case Report and Brief Literature Review

“…Intralesional interleukin-2 (IL-2) injections have been used successfully to treat cutaneous metastases in other cancers, including melanoma ( 5 ) and porocarcinoma ( 6 ). However, the use of IL-2 in the treatment of breast cancer is not well-described, with a single case study published in 2021 reporting a pathologic complete response after intralesional IL-2 injections in a patient with triple-negative breast cutaneous cancer metastasis ( 7 ).…”