Resolution of inflammation: An organizing principle in biology and medicine

Panigrahy, Dipak; Gilligan, Molly M.; Serhan, Charles N.; Kashfi, Khosrow

doi:10.1016/j.pharmthera.2021.107879

Cited by 151 publications

(93 citation statements)

References 230 publications

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“…On this matter, the products of the IsoP or NeuroP pathway were found to have strong biological actions and may therefore participate as physiological mediators of different diseases [16,17]. In particular, n-6 PUFA derivatives resulting from arachidonic acid (ARA) have prothrombotic and pro-aggregatory properties, whereas n-3 PUFA metabolites resulting from EPA and DHA have anti-inflammatory, antiproliferative, and anti-atherosclerotic activities [18,19]. Furthermore, cardiac antiarrhythmic properties have been reported for 4(RS)-4-F 4t -neuroprostane [20].…”

Section: Introductionmentioning

confidence: 99%

F4-Neuroprostanes: A Role in Sperm Capacitation

Signorini

Moretti

Noto

et al. 2021

Life

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F4-neuroprostanes (F4-NeuroPs), derived from the oxidative metabolization of docosahexaenoic acid (DHA), are considered biomarkers of oxidative stress in neurodegenerative diseases. Neurons and spermatozoa display a high DHA content. NeuroPs might possess biological activities. The aim of this in vitro study was to investigate the biological effects of chemically synthetized 4-F4t-NeuroP and 10-F4t-NeuroP in human sperm. Total progressive sperm motility (p < 0.05) and linearity (p = 0.016), evaluated by a computer-assisted sperm analyzer, were significantly increased in samples incubated with 7 ng F4-NeuroPs compared to non-supplemented controls. Sperm capacitation was tested in rabbit and swim-up-selected human sperm by chlortetracycline fluorescence assay. A higher percentage of capacitated sperm (p < 0.01) was observed in samples incubated in F4-NeuroPs than in the controls. However, the percentage of capacitated sperm was not different in F4-NeuroPs and calcium ionophore treatments at 2 h incubation. The phosphorylated form of AMPKα was detected by immunofluorescence analysis; after 2 h F4-NeuroP incubation, a dotted signal appeared in the entire sperm tail, and in controls, sperm were labeled in the mid-piece. A defined level of seminal F4-NeuroPs (7 ng) showed a biological activity in sperm function; its addition in sperm suspensions stimulated capacitation, increasing the number of sperm able to fertilize.

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Section: Introductionmentioning

confidence: 99%

F4-Neuroprostanes: A Role in Sperm Capacitation

Signorini

Moretti

Noto

et al. 2021

Life

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“…It is characterized by the activation of immune cells, synthesis of proinflammatory mediators, is usually localized and self-limited, and normally returns to homeostasis [75]. Acute inflammation requires suppression of proinflammatory mediators and induction of antiinflammatory/proresolution mediators as well as the disappearance of leukocytes from the damage area, and the restoration of tissue functionality [76]. However, if the acute inflammatory process is excessive and is not resolved, it may lead to tissue damage, resulting in chronic inflammation, and ultimately fibrosis, with loss of tissue functionality.…”

Section: Inflammation and Cancermentioning

confidence: 99%

“…As mentioned above, after the active phase of inflammation, coordinated resolution responses are initiated to prevent chronic inflammation establishment and restore homeostasis [76]. During the initial phase of the acute inflammatory response, the well-known proinflammatory mediators comprising prostaglandins (PGs) and leukotrienes are synthesized from arachidonic acid (ARA) by cyclooxygenases (COXs) and lipoxygenases.…”

Section: Inflammation and Cancermentioning

confidence: 99%

“…Additionally, EET, and other epoxy fatty acids, stimulate the production of specialized proresolving mediators (SPMs), such as lipoxins, by shifting ARA metabolism, to support inflammation resolution [91]. In addition to omega-6 arachidonic acid-derived lipoxins, n-3 PUFA-derived SPMs are synthesized from EPA and docosahexaenoic acid and encompass resolvins, protectins, and maresins [76,92]. These lipid autacoids are involved in down-regulation of proinflammatory cytokines/chemokines, inhibition of neutrophil infiltration, and induction of macrophage phagocytosis [93].…”

Section: Inflammation and Cancermentioning

confidence: 99%

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Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

et al. 2021

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Acute inflammation is a key component of the immune system’s response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the development of many diseases, including cancer. Nowadays, the need to find new potential therapeutic compounds has raised the worldwide scientific interest to study the marine environment. Specifically, microalgae are considered rich sources of bioactive molecules, such as carotenoids, which are natural isoprenoid pigments with important beneficial effects for health due to their biological activities. Carotenoids are essential nutrients for mammals, but they are unable to synthesize them; instead, a dietary intake of these compounds is required. Carotenoids are classified as carotenes (hydrocarbon carotenoids), such as α- and β-carotene, and xanthophylls (oxygenate derivatives) including zeaxanthin, astaxanthin, fucoxanthin, lutein, α- and β-cryptoxanthin, and canthaxanthin. This review summarizes the present up-to-date knowledge of the anti-inflammatory and anticancer activities of microalgal carotenoids both in vitro and in vivo, as well as the latest status of human studies for their potential use in prevention and treatment of inflammatory diseases and cancer.

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“…En este sentido, a futuro se debería incentivar la realización de estudios moleculares de identificación bacteriana, con la finalidad de identificar microorganismos que puedan estar implicados en la génesis y/o mantenimiento del conducto con exudado persistente. Así mismo, en razón del inherente carácter inflamatorio de esta condición clínica, se debería incentivar estudios encaminados a determinar mecanismos moleculares inflamatorios que podrían estar implicados, como podría ser por ejemplo, la carencia o disminución de factores esenciales en la fase de resolución de la inflamación, como la superfamilia de los mediadores pro-resolución especializados (Panigrahy et al, 2021;Serhan et al, 2020), lo que podría derivar incluso en posibles aplicaciones terapéuticas futuras.…”

Section: Conclusionesunclassified

Conducto con exudado persistente: Causas y manejo clínico

Álvarez-Vásquez

Fernández

Ortiz

2021

RSD

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Objetivo: El objetivo de esta revisión integrativa de la literatura fue abordar las causas y manejo clínico del conducto con exudado persistente o “conducto llorón”, que es una entidad clínica caracterizada por la presencia intraconducto de exudado inflamatorio persistente, pese al tratamiento de conducto en ejecución, incluso después de varias citas. Metodología: Se realizó un levantamiento bibliográfico en las bases de datos Pubmed, Scopus y EBSCO, en idioma inglés y sin restricción de fecha de publicación. Los términos de búsqueda empleados en combinación fueron: conducto húmedo, conducto llorón, exudado persistente, exudación intraconducto persistente y, tratamiento de conducto radicular. Resultados y conclusión: Se concluye que la causa principalmente descrita es la microbiana, en forma de biofilm bacteriano o infección recalcitrante. Respecto a su manejo clínico, existen disponibles una serie de abordajes, como las puntas de papel, la medicación intraconducto y sistemas de aspiración como el EndoVac, en tanto que el empleo de la terapia con láser Nd:YAG requiere de más estudios que respalden su uso clínico.

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Resolution of inflammation: An organizing principle in biology and medicine

Cited by 151 publications

References 230 publications

F4-Neuroprostanes: A Role in Sperm Capacitation

F4-Neuroprostanes: A Role in Sperm Capacitation

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

Conducto con exudado persistente: Causas y manejo clínico

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