Resolution of hyperlipidemia follows surgical weight loss in patients undergoing Roux-en-Y gastric bypass surgery: a 6-year analysis of data

Jamal, Mohammad; Wegner, Robert; Heitshusen, Debi; Liao, Junlin; Samuel, Isaac

doi:10.1016/j.soard.2010.08.009

Cited by 44 publications

(23 citation statements)

References 26 publications

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“…After 1 year all patients had total cholesterol levels within the normal reference. Our results follow the observations already arranged in the literature (23) . The fractions of LDL-C and triglycerides decreased significantly in short and long term, but showed no significant difference between age groups and gender in response to surgery.…”

Section: Discussionsupporting

confidence: 93%

“…It seems to be a common pattern that the effects on lipid fractions occur much more gradual than those found in glucose metabolism, for example. Several studies show a gradual improvement of the lipid fractions and suggests that the highest levels are found only 2 years after the procedure (23,34) . In contrast of other lipid fractions the effects of gastric bypass on HDL-C showed different and conflicting results between genders and age groups.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast of other lipid fractions the effects of gastric bypass on HDL-C showed different and conflicting results between genders and age groups. Some authors suggest that the response of HDL-C is represented graphically by a "U" curve-shaped, with a decrease in the first month and a gradual increase after 6 months of surgery (3,23) . In fact, the average values found in our study groups suggest the formation of this curve, but in a discreet manner and with values without statistical change.…”

Section: Discussionmentioning

confidence: 99%

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AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

Andrade-Silva

Caranti

Sallet³

et al. 2014

Arq. Gastroenterol.

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-Context -Severe obesity affects the body favoring the development of serious diseases, including hypertension, diabetes mellitus, atherosclerosis and non alcoholic fatty liver disease. Bariatric procedures increased in Brazil in the last decade. Objectives -The purpose of this study was to verify if gender and age in date of procedure resulted significant differences in metabolic syndrome parameters after surgery. Methods -The study involved 205 medical records of adult patients undergoing Roux-en-Y gastric bypass, stratified by gender and age groups and followed one year by a multidisciplinary team. Results -It was observed significant decrease in body mass index, fasting glucose and insulin at all ages and both genders. Lipid profile showed significant improvements except high density lipoprotein cholesterol. Ectopic fat in the liver has decreased after 6 months in patients classified with steatosis at baseline. Patients classified as hypertensive blood pressure levels decreased 6 months after surgical intervention. Conclusion -Roux-en-Y gastric bypass proved to be an important tool in remission of metabolic syndrome parameters. The reduction of body mass accompanied to decrease in insulin resistance resulted in lower prevalence of comorbidities associated with obesity. The benefits were similar and extended both genders and all age groups between 18 and 65 years old. HEADINGS -Bariatric surgery. Metabolic syndrome X. Roux-en-Y anastomosis. Fatty liver.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

Andrade-Silva

Caranti

Sallet³

et al. 2014

Arq. Gastroenterol.

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“…RYGB-and VSGinduced weight loss significantly improves the lipid profile of previously obese patients within 1 year. 27,28 Both our patients had a decrease in low-density lipoprotein and an increase in highdensity lipoprotein levels after surgery (Table 1). Patient A also demonstrated dramatic improvement in his symptoms of OSA, which has been shown to be independently associated with CVD.…”

Section: Discussionmentioning

confidence: 70%

Bariatric Surgery for Severe Obesity in Two Adolescents With Type 1 Diabetes

Chuang

Zeller²,

Inge

et al. 2013

Pediatrics

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Bariatric surgery has been effective in treating type 2 diabetes mellitus (T2DM); it has not been used frequently in obese patients with type 1 diabetes mellitus (T1DM). This is the first case series reporting on the effect of bariatric surgery on diabetes control in adolescents with T1DM. Patient A is a 19-year-old obese man with T1DM who underwent vertical sleeve gastrectomy. At 12 months after surgery he demonstrated 28% reduction in BMI. His daily total insulin requirement had decreased; however, hemoglobin A1c remained primarily unchanged at 8.8%. Patient B is a 13-year-old obese girl with an initial clinical diagnosis of T2DM controlled on only metformin. She underwent Roux-en-Y gastric bypass; at 1 month after surgery she presented in diabetic ketoacidosis and was found to have positive islet cell antibodies, which were also present before surgery. Her diagnosis was revised to T1DM, and she was started on insulin. By 28 months after surgery her BMI had decreased by 42%. Since initiation of insulin, her daily total insulin requirement had decreased, but hemoglobin A1c had significantly worsened from 6.3% to 10%. We found that despite significant weight loss, improvements in cardiovascular risk factors (dyslipidemia and obstructive sleep apnea), and quality of life in our patients, bariatric surgery does not necessarily lead to improved glycemic control of T1DM. Patients with T1DM have ongoing dependency on exogenous insulin, and optimal glycemic control still depends on patient compliance with diabetes care. Pediatrics 2013;132:e1031-e1034 Dr Chuang conceptualized the case series and drafted the initial manuscript; Dr Zeller interpreted the quality of life measurements used in the case series, wrote the interpretations for the manuscript, and reviewed and revised the manuscript; Dr Inge helped obtain data used in the case series and critically reviewed and revised the manuscript; Dr Crimmins help conceptualize and design the outline for the case series and critically reviewed and revised the manuscript; and all authors approved the final manuscript as submitted.

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“…The criteria were systolic blood pressure >140 mmHg and/or diastolic blood pressure >90 mmHg or current treatment with antihypertensive agents. Diabetes mellitus was defined according to the American Diabetes Association guidelines [18]. It was defined as two fasting plasma glucose of more than 125 mg/dL or current treatment with oral hypoglycemic agents or insulin.…”

Section: Patients and Study Designmentioning

confidence: 99%

Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran

Fallahi-shahabad

Mazidi

Tavasoli

et al. 2016

Indian J Gastroenterol

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Resolution of hyperlipidemia follows surgical weight loss in patients undergoing Roux-en-Y gastric bypass surgery: a 6-year analysis of data

Cited by 44 publications

References 26 publications

AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

Bariatric Surgery for Severe Obesity in Two Adolescents With Type 1 Diabetes

Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran

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