Resolution of eating disorders after right temporal lesions

Levine, Reed

doi:10.1016/s1525-5050(03)00213-0

Cited by 4 publications

(4 citation statements)

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“…[31][32][33][34][35][36][37][38] The damage was predominantly localised in the frontal and temporal lobes (six frontal, four temporal, three frontotemporal) of the right hemisphere (nine right, three left, one bilateral). In eight cases, there was evidence suggestive of causal association between the lesion and eating disorder.…”

Section: Hemispheric Lesionsmentioning

confidence: 99%

Brain lesions and eating disorders

Uher

Treasure

2005

Journal of Neurology, Neurosurgery & Psychiatry

146

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Objective: To evaluate the relation between lesions of various brain structures and the development of eating disorders and thus inform the neurobiological research on the aetiology of these mental illnesses. Method: We systematically reviewed 54 previously published case reports of eating disorders with brain damage. Lesion location, presence of typical psychopathology, and evidence suggestive of causal association were recorded. Results: Although simple changes in appetite and eating behaviour occur with hypothalamic and brain stem lesions, more complex syndromes, including characteristic psychopathology of eating disorders, are associated with right frontal and temporal lobe damage. Conclusions: These findings challenge the traditional view that eating disorders are linked to hypothalamic disturbance and suggest a major role of frontotemporal circuits with right hemispheric predominance in the pathogenesis.

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Section: Hemispheric Lesionsmentioning

confidence: 99%

Brain lesions and eating disorders

Uher

Treasure

2005

Journal of Neurology, Neurosurgery & Psychiatry

146

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“…When anorexic patients viewed images of their own body which they had themselves digitally distorted there was activity in the right amygdala, the right fusiform gyrus and brainstem region, as if a 'fear network' had been triggered (Seeger et al, 2002). Likewise, anorexic and bulimic patients were reported to recover after right temporal lobe injuries (Levine et al, 2003), suggesting the dependence of anorexia on function in the right hemisphere.…”

Section: Introductionmentioning

confidence: 99%

Anodal transcranial direct current stimulation over the dorsolateral prefrontal cortex improves anorexia nervosa: A pilot study

Khedr

El-Fetoh

Ali

et al. 2014

Restorative Neurology and Neuroscience

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Background: Existing treatments for adults with anorexia nervosa (AN) have limited proven efficacy. New treatments that have been suggested involve targeted, brain-directed interventions such as transcranial direct current stimulation (tDCS). We describe findings from seven individuals with treatment-resistant AN who received 10 sessions of anodal tDCS, over the left dorsolateral prefrontal cortex (DLPFC). Material and method:In this open-label, single-arm study, seven patients received anodal tDCS (2mA) for 25 minutes over the left dorsolateral prefrontal cortex daily for ten days. Assessments pre-tDCS, post-tDCS and one month later included the Eating Attitude Test (EAT), Eating Disorder Inventory (EDI) and Beck Depression Inventory (BDI). Results: Three patients improved in all three rating scales immediately after the treatment sessions and one month later. Two patients showed improvement at the end of treatment but returned to the baseline after one month. One subject improved only on the BDI scale but not eating scales. The scores in the three rating scales were unaffected by treatment in the remaining patient. There was a significant effect of time (pre, post and 1 month later) on the three rating scores; BDI (P = 0.016), EDI (P = 0.018) and EAT (P = 0.016) and a significant correlation between the percent improvement of BDI and EAT (p = 0.01), and between BDI and EDI (P = 0.006). Conclusions: These findings suggest that tDCS has potential as an adjuvant treatment for AN and deserves further study.

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“…Two of these latter patients recovered from the eating disorder following treatment and the third remained in a vegetative state after a right frontal hemorrhagic infarction. Levine et al 8 reported another case showing medically refractory epilepsy and anorexia nervosa, the patient's eating disorder resolved after suffering a head injury that resulted in right-sided inferofrontal and temporal encephalomalacia. In addition, several reports have linked epilepsy with changes in appetitive behavior, especially temporal lobe epilepsy.…”

Section: Resultsmentioning

confidence: 99%