Resolution of conglomerates with the assistance of tailor-made impurities. Generality and mechanistic aspects of the "rule of reversal". A new method for assignment of absolute configuration

Emergence of a Single Solid Chiral State from a Nearly Racemic Amino Acid Derivative

“…In the † Radboud University Nijmegen. latter case, Lahav's "rule of reversal" 18,19 applies. The continued fragmentation of crystals by attrition also provides a relative increase in the surface area of the hand that has established an excess.…”

Effect of additives on the preferential crystallization of L-asparagine monohydrate

“…It may inhibit either growth or nucleation, or more rarely promote growth or nucleation, or it may alter the shape or morphology of the crystals. Addadi et al proposed the rule of reversal, which suggests that additives most easily adsorb on the surface of the crystal that has the same absolute configuration as the additive [19,20]. The rule thus states that the chiral additive will inhibit the crystallization of the enantiomorph similar in chirality to the additive.…”

Biomimetic Polymers for Chiral Resolution and Antifreeze Applications

“…[131][132][133][134][135][136] They found that the incorporation of a small amount (up to a few percent) of enantiomerically-pure additives in the crystallization of chiral systems inhibits the crystallization of one enantiomer dramatically. In their study, Lahav and Leiserowitz encountered the interesting phenomenon of asymmetric induction on the crystallization of non-chiral photopolymerizable dienes into chiral crystals.…”