Resolution of anisometropic amblyopia in a 48‐year‐old with refractive correction alone

Gao, Tina; Guo, Cindy X.; South, Jayshree; Black, Joanna; Dai, Shuan; Anstice, Nicola; Thompson, Benjamin

doi:10.1111/cxo.12457

Cited by 5 publications

(9 citation statements)

References 11 publications

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“…Subjects in the current study received new spectacles with the proper refractive correction at baseline. Initiating the use of appropriate prescription glasses can improve amblyopia in children 41 and adults 42 , 43 . Therefore, the use of new corrective lenses may have added to the visual gains observed in the current study.…”

Section: Discussionmentioning

confidence: 99%

Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia

Huttunen

Palva

Lindberg

et al. 2018

Sci Rep

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Amblyopia is a common visual disorder that is treatable in childhood. However, therapies have limited efficacy in adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision in adult rats with amblyopia. We conducted a Phase 2, randomized (fluoxetine vs. placebo), double-blind, multicenter clinical trial examined whether or not fluoxetine can improve visual acuity in amblyopic adults. This interventional trial included 42 participants diagnosed with moderate to severe amblyopia. Subjects were randomized to receive either 20 mg fluoxetine (n = 22) or placebo (n = 20). During the 10-week treatment period, all subjects performed daily computerized perceptual training and eye patching. At the primary endpoint, the mean treatment group difference in visual acuity improvement was only 0.027 logMAR units (95% CI: −0.057 to 0.110; p = 0.524). However, visual acuity had significantly improved from baseline to 10 weeks in both fluoxetine (−0.167 logMAR; 95% CI: −0.226 to −0.108; p < 0.001) and placebo (−0.194 logMAR; 95% CI: −0.254 to −0.133; p < 0.001) groups. While this study failed to provide evidence that fluoxetine enhances neuroplasticity, our data support other recent clinical studies suggesting that improvement of vision can be accomplished in adults with amblyopia.

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Section: Discussionmentioning

confidence: 99%

Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia

Huttunen

Palva

Lindberg

et al. 2018

Sci Rep

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show abstract

“…Subjects in the current study received new spectacles with the proper refractive correction at baseline. Initiating the use of appropriate prescription glasses can improve amblyopia in children 44 and adults 45 . Therefore, the use of new corrective lenses may have added to the visual gains observed in the current study.…”

Section: Discussionmentioning

confidence: 99%

Effect of fluoxetine on adult amblyopia: a placebo-controlled study combining neuroplasticity-enhancing pharmacological intervention and perceptual training

Huttunen

Palva

Lindberg³

et al. 2018

Preprint

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“…A subgroup of nine (one child, four teenagers, and four adults) ineligible participants consented to attend additional follow-up visits outside the clinical trial protocol, including one adult previously described. 32 Our aim was to assess possible further improvements after DVA had improved beyond 0.30 logMAR not captured by the main study analyses. All nine participants in this subgroup received new spectacles at the optical treatment baseline, and one adult also wore contact lenses once per week.…”

Section: -Week Follow-upmentioning

confidence: 99%

“…This possibility led us to apply the same standard optical treatment protocol to all participants in the Binocular treatment for amblyopia using videogames (BRAVO) clinical trial (Australian New Zealand Clinical Trails Registry, ID: ACTRN12613001004752). We have previously reported the case of a 48‐year‐old participant with anisometropic amblyopia in this study who demonstrated significant improvements after four weeks of spectacle wear . Building on this work, we present here the completed pre‐randomisation dataset from this clinical trial to evaluate the effects of age, prior treatment history, and type of amblyopia on visual outcomes from optical treatment.…”

Section: Introductionmentioning

confidence: 96%

“…We have previously reported the case of a 48-year-old participant with anisometropic amblyopia in this study who demonstrated significant improvements after four weeks of spectacle wear. 32 Building on this work, we present here the completed pre-randomisation dataset from this clinical trial to evaluate the effects of age, prior treatment history, and type of amblyopia on visual outcomes from optical treatment.…”

Section: Introductionmentioning

confidence: 99%

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Optical treatment of amblyopia in older children and adults is essential prior to enrolment in a clinical trial

Gao

Anstice

Babu

et al. 2018

Ophthalmic Physiologic Optic

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Resolution of anisometropic amblyopia in a 48‐year‐old with refractive correction alone

Cited by 5 publications

References 11 publications

Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia

Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia

Effect of fluoxetine on adult amblyopia: a placebo-controlled study combining neuroplasticity-enhancing pharmacological intervention and perceptual training

Optical treatment of amblyopia in older children and adults is essential prior to enrolment in a clinical trial

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