Resolution of an Artificially Induced Hematoma and the Influence of a Proteolytic Enzyme

Dietary Supplements

“…80 Bromelain is more effective at resorbing hematomas when given preoperatively. 80 The exact mechanism of hematoma resorption is unknown. The inhibition of plasma exudation may help bromelain resorb hematomas.…”

“…Derived from the stem of the pineapple plant, bromelain possesses anti‐inflammatory activity and has been shown to facilitate burn débridement 78,79 . Bromelain has shown the ability to increase the resorption rate of hematomas, as shown in a blinded placebo‐controlled study of eyelid and forearm hematomas in humans 80 . Bromelain is more effective at resorbing hematomas when given preoperatively 80 .…”

“…Bromelain has shown the ability to increase the resorption rate of hematomas, as shown in a blinded placebo‐controlled study of eyelid and forearm hematomas in humans 80 . Bromelain is more effective at resorbing hematomas when given preoperatively 80 . The exact mechanism of hematoma resorption is unknown.…”

Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature

“…Five studies reported improvement of ecchymosis and/or edema after use of bromelain post procedure. [36][37][38][39][40] Two studies revealed no improvement for use of bromelain post procedure. 41,42 Analysis and Recommendation Three RCTs noted significant improvement of ecchymosis and edema post facial procedures, and 2 RCTs demonstrated similar positive findings post dental procedures.…”

Nutritional supplements and surgical patients

“…It acts as an anti‐inflammatory and a digestive aid, and it has been used topically as a burn‐debriding agent 18 . In one well‐designed placebo‐controlled study, researchers found that bromelain decreased surgical patients' time required for hematoma resorption 19 . Patients should receive a dose of 500 mg as soon as possible postoperatively and take further doses on an empty stomach four times per day until the hematoma or swelling has resolved.…”