Resolution of a triazol-containing compound through co-crystallisation

Abstract

Title of the poster: Resolution of a triazol-containing compound through co-crystallisation Triazoles are a special class of heterocyclic compounds with a broad spectrum of biological activities such as antimicrobial, cytotoxic, antihistaminic, anti-inflammatory or anticancer [1] , consequently very interesting for pharmaceutical companies. Moreover, in those industries, 50% of the marketed drug compounds contain a chiral center [2] , essential to their functioning. Where one enantiomer has the desired pharmacological effect, the other might be inactive or have adverse effects (e.g. Thalidomide). In spite of important advances in asymmetric synthesis, the most prominent way to chiral drugs still involves formation of a racemic compound followed by its resolution by a physical process.