Resolution of a factor that enhances the antibody response of T cell-depleted murine splenocytes from several other monocyte products

Immunosuppression in murine malaria: Suppressor role of macrophages and their products during acute and chronic Plasmodium berghei infection

“…Adherent peritoneal cells of the mouse have been shown to produce a soluble factor in response to LPS that converts antigen stimulated cells to antibody secreting cells but does not induce mitosis of B cells (9). Similar factors have been reported by Schrader ( 17) in murine peritoneal cells and by Wood et al (23). Our adoptive transfer studies revealed that when macrophages were transferred from acutely infected animals to normal recipients, suppression in plaque forming cells was observed in the recipeint animals receiving macrophages from infected animals at all levels of parasitaemia.…”

Interleukin 1 and T-cell activation

“…of approximately 18,000. In addition to the studies of Gery et al (1972), and Wood et al (1976), Calderon et al (1975) also found that peritoneal macrophages produced 15,000-21,000 m.w. factors that were capable of stimulated thymocyte proliferation as well as in vitro antibody responses to particulate antigens.…”

“…It is again quite likely that IL 1 is acting in part via the induction of IL 2 to increase the frequency of helper T cells, especially in view of the ability of IL 2 to promote helper T cell proliferation (Watson 1979). However, Wood (Wood & Gaul 1974, Wood et al 1976, Wood 1979) and Hoffman , 1980, Hoffman 1980 have argued that IL 1 may also directly affect B cells. Hoffman has presented evidence indicating that IL 1 can I) enhance the expression of several B cell surface markers (surface immunoglobulin, complement receptors and la) and increase the frequency of reactive B cells (Hoffman 1980).…”

Interleukin 2: A Class of T Cell Growth Factors

“…The distinction between human IL 1 and IL 2 is particularly interesting as they may be similar in size and charge, and possess similar stimulatory activities in a number of murine assay systems. It appears likely that the factors obtained from human adherent, peripheral blood lymphocytes with LAF activity (Lachman et al 1977, Togawa et al 1979), costimulator and helper T cell-replacing activity (Koopman et al 1977, and B cell-activating factor (Wood et al 1976, Wood 1977Wood and Cameron, 1978) are, in fact, due to the presence of IL L However, the formal delineation of human IL 1 and IL 2 activities in these assay systems remains to be demonstrated.…”