Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes
Chi-Wei Liu,
Hsuan-Yu Peng,
An-Ci Siao
et al.
Abstract:Resistin and suppressors of cytokine signaling (SOCSs) have been reported to regulate prostate cancer (PCa) cell proliferation and survival, respectively. Whether any of the SOCS molecules mediate the mitogenic effect of resistin on PCa cells is unknown. Using PC-3 human PCa cells, we found that resistin upregulates the expression of SOCS3 and SOCS5 mRNA, but not SOCS7 mRNA, in a dose- and time-dependent manner. The resistin-induced increases in SOCS3 and SOCS5 expression and cell proliferation were prevented … Show more
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