Resistin is an inflammatory marker of inflammatory bowel disease in humans

Konrad, Astrid; Lehrke, Michael; Schachinger, Veronika; Seibold, Frank; Stark, Renée; Ochsenkühn, Thomas; Parhofer, Klaus G.; Göke, Burkhard; Broedl, Uli C.

doi:10.1097/meg.0b013e3282f16251

Cited by 129 publications

(90 citation statements)

References 24 publications

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“…Increased serum resistin levels have been detected in both Crohn's disease and ulcerative colitis patients [120,121,122]. In addition, resistin correlated with the disease activity score, white blood cell count, and CRP in patients with Crohn's disease [121,122].…”

Section: Resistin and Inflammatory Bowel Diseasesmentioning

confidence: 96%

“…In addition, resistin correlated with the disease activity score, white blood cell count, and CRP in patients with Crohn's disease [121,122]. In contrast to leptin and adiponectin, resistin significantly decreases after TNF-α blocking therapy in patients with inflammatory bowel diseases and has been proposed as a marker of successful therapy, similar to the patients with rheumatoid arthritis [123].…”

Section: Resistin and Inflammatory Bowel Diseasesmentioning

confidence: 97%

“…Resistin has been suggested as an independent predictor of disease activity in patients with inflammatory bowel disease and has been proposed as a marker of successful therapy [121,123]. Moreover, RELM-β has anti-parasitic effects and may play a role in the pathology of inflammatory bowel diseases.…”

Section: Resistin and Inflammatory Bowel Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Filková

Haluzı́k

Šenolt

2009

Clinical Immunology

358

290

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Section: Resistin and Inflammatory Bowel Diseasesmentioning

confidence: 96%

Section: Resistin and Inflammatory Bowel Diseasesmentioning

confidence: 97%

See 1 more Smart Citation

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Filková

Haluzı́k

Šenolt

2009

Clinical Immunology

358

290

View full text Add to dashboard Cite

“…Resistin in humans appears to have a significant proinflammatory role by targeting PBMCs, endothelial cells, smooth muscle cells, platelets (30), and chondrocytes (31) and by increasing the release of IL-1β, IL-6, and TNF-α via the NF-κB pathway (32). Resistin has been reported to be a marker of inflammation in systemic lupus erythematosus (SLE) and Crohn's disease in humans (33). It is unclear at this time why resistin had this unusual behavior in our study, increasing with mild to moderate disease severity but decreasing with moderate to severe disease.…”

Section: Discussionmentioning

confidence: 99%

Cytokine signature associated with disease severity in chronic fatigue syndrome patients

Montoya

Holmes

Anderson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

295

251

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Although some signs of inflammation have been reported previously in patients with myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), the data are limited and contradictory. High-throughput methods now allow us to interrogate the human immune system for multiple markers of inflammation at a scale that was not previously possible. To determine whether a signature of serum cytokines could be associated with ME/CFS and correlated with disease severity and fatigue duration, cytokines of 192 ME/CFS patients and 392 healthy controls were measured using a 51-multiplex array on a Luminex system. Each cytokine’s preprocessed data were regressed on ME/CFS severity plus covariates for age, sex, race, and an assay property of newly discovered importance: nonspecific binding. On average, TGF-β was elevated (P = 0.0052) and resistin was lower (P = 0.0052) in patients compared with controls. Seventeen cytokines had a statistically significant upward linear trend that correlated with ME/CFS severity: CCL11 (Eotaxin-1), CXCL1 (GROα), CXCL10 (IP-10), IFN-γ, IL-4, IL-5, IL-7, IL-12p70, IL-13, IL-17F, leptin, G-CSF, GM-CSF, LIF, NGF, SCF, and TGF-α. Of the 17 cytokines that correlated with severity, 13 are proinflammatory, likely contributing to many of the symptoms experienced by patients and establishing a strong immune system component of the disease. Only CXCL9 (MIG) inversely correlated with fatigue duration.

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“…In adult patients with sepsis, resistin was implicated as an effective biomarker of sepsis severity and as a predictor of mortality of critically ill adult patients. Also, Serum resistin levels were elevated in patients with inflammatory bowel disease and it was correlated with CRP, TLC levels and with the disease activity [16]. In a study done by Adrych et al, they reported that serum-resistin levels were elevated in patients with chronic pancreatitis and they suggested its role in the development of pancreatic fibrosis [17].…”

mentioning

confidence: 94%

Studying the efficacy of resistin as a diagnostic biomarker of neonatal sepsis

Ahmed¹,

Botrous²,

Doudar³

et al. 2018

Med-Science

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Sepsis is an important cause of neonatal death and perinatal brain damage, particularly in preterm infants. It is thought that activation of the inflammatory cascade triggered by cytokine may play a role in the pathogenesis of sepsis. Recent evidence supports a role for resistin in inflammation. There are no data in the literature on resistin levels in neonates with sepsis, which can also cause an inflammatory response. The objective of this study was to evaluate the role of resistin as an indicator in neonatal sepsis. Forty neonates considered to have sepsis were included in the study. Forty gestational and postnatal age-and sex-matched neonates without prolonged premature rupture of membrane or sepsis had served as controls. The mean resistin level of the neonates with sepsis was 115 ng/mL and was higher than those of the control group (41.1 ng/ mL ). There was statistically significant direct correlations between serum resistin and both TLC and CRP. The sensitivity, specificity, positive, and negative predictive values for resistin were 100%, 93%, 96%, and 100%, respectively. Resistin levels were higher in newborns with sepsis and correlated with TLC and CRP levels, which are indicators of neonatal sepsis. This suggests that resistin may also be used in the diagnosis of neonatal sepsis.

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Resistin is an inflammatory marker of inflammatory bowel disease in humans

Abstract: Resistin levels are an independent predictor of disease activity in patients with CD. Resistin may represent a novel link between inflammation and IBD.

Cited by 129 publications

References 24 publications

The role of resistin as a regulator of inflammation: Implications for various human pathologies

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Cytokine signature associated with disease severity in chronic fatigue syndrome patients

Studying the efficacy of resistin as a diagnostic biomarker of neonatal sepsis

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