Resistin in inflammatory and degenerative rheumatologic diseases

Fadda, Samia H.; Gamal, Sherif M.; Elsaid, Nora Y.; Mohy, Abeer

doi:10.1007/s00393-013-1146-5

Cited by 29 publications

(15 citation statements)

References 37 publications

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“…These findings, together with the observation that the intra-articular injection of resistin in the knee joints induces arthritis, sustain the involvement of resistin in RA pathogenesis [110]. Several reports have demonstrated that serum resistin levels are significantly higher in RA than in OA patients or healthy controls [111–113]. The increased serum levels of resistin correlated with markers of inflammation, such as CRP, ESR, IL-1Ra, and total leukocyte count [47, 114–117], disease activity (DAS28), and joint destruction [112].…”

Section: Resistinmentioning

confidence: 74%

“…The increased serum levels of resistin correlated with markers of inflammation, such as CRP, ESR, IL-1Ra, and total leukocyte count [47, 114–117], disease activity (DAS28), and joint destruction [112]. However, these results were not confirmed by other groups [111], and conflicting results were reported on the association between resistin and radiographic progression signs [27, 31, 100]. Recently, the anti-TNF- α therapy was reported to modulate resistin levels in RA patients [118, 119] (Table 1).…”

Section: Resistinmentioning

confidence: 99%

“…These results strongly suggest that resistin production is elevated at the site of inflammation and accumulates in the synovial fluid of RA patients. In anti-CCP positive patients, synovial fluid resistin levels, but not serum levels, correlated with disease progression suggesting resistin as a disease progression marker [111]. …”

Section: Resistinmentioning

confidence: 99%

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Adipokines as Potential Biomarkers in Rheumatoid Arthritis

Prete

Salvi

Sozzani

2014

Mediators of Inflammation

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Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease characterized by severe joint injury. Recently, research has been focusing on the possible identification of predictor markers of disease onset and/or progression, of joint damage, and of therapeutic response. Recent findings have uncovered the role of white adipose tissue as a pleiotropic organ not only specialized in endocrine functions but also able to control multiple physiopathological processes, including inflammation. Adipokines are a family of soluble mediators secreted by white adipose tissue endowed with a wide spectrum of actions. This review will focus on the recent advances on the role of the adipokine network in the pathogenesis of RA. A particular attention will be devoted to the action of these proteins on RA effector cells, and on the possibility to use circulating levels of adipokines as potential biomarkers of disease activity and therapeutic response.

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Section: Resistinmentioning

confidence: 74%

Section: Resistinmentioning

confidence: 99%

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Adipokines as Potential Biomarkers in Rheumatoid Arthritis

Prete

Salvi

Sozzani

2014

Mediators of Inflammation

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“…In addition, resistin levels are found to be higher in the serum and synovial fluid of RA patients than in those with osteoarthritis (OA). The observed statistically significant correlation between synovial fluid resistin levels and rheumatoid factor (RF), anti-citrufllinated protein/peptide autoantibody (ACPA) and Larsen score which further indicate that locally produced adipokines are closely implicated in synovial inflammation during the pathogenesis of RA 38 .…”

Section: Discussionmentioning

confidence: 89%

Adiponectin exacerbates collagen-induced arthritis via enhancing Th17 response and prompting RANKL expression

Sun

Feng

Tan

et al. 2015

Sci Rep

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We previously reported adiponectin (AD) is highly expressed in the inflamed synovial joint tissue and correlates closely with progressive bone erosion in Rheumatoid arthritis (RA) patients. Here, we investigate the role of adiponectin in regulating Th17 response and the expression of receptor activator of nuclear factor-κB ligand (RANKL) in mice with CIA mice by intraarticularly injection of adiponectin into knee joints on day 17, day 20 and day 23 post first collagen immunization. The increased adiponectin expression was found in inflamed joint tissue of collagen-induced arthritis (CIA) mice. Adiponectin injection resulted in an earlier onset of arthritis, an aggravated arthritic progression, more severe synovial hyperplasia, bone erosion and osteoporosis in CIA mice. CD4+IL-17+ Th17 cells, IL-17 mRNA and RANKL mRNA expression were markedly increased in the joint tissue of adiponectin treated CIA mice. Moreover, adiponectin treatment markedly enhanced Th17 cell generation from naive CD4+ T cells in vitro, which accompanied by the high expression of Th17 transcription factor ROR-γt, and Th17 cytokine genes included IL-22 and IL-23. This study reveals a novel effect of adiponectin in exacerbating CIA progression by enhancing Th17 cell response and RANKL expression.

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“…It acts as a pro-inflammatory factor that increases the production of inflammatory cytokines and elevates the expression of cell adhesion molecules. While its exact biologic functions are still being elucidated, higher resistin levels have been associated with chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease, and resistin may play a role in the pathophysiology of atherosclerosis and endothelial cell injury [ 86 , 87 ].…”

Section: Introduction Of Adipocytokinesmentioning

confidence: 99%

Adipocytokines in renal transplant recipients

et al. 2016

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In the last two decades, perceptions about the role of body fat have changed. Adipocytes modulate endocrine and immune homeostasis by synthesizing hundreds of hormones, known as adipocytokines. Many studies have been investigating the influences and effects of these adipocytokines and suggest that they are modulated by the nutritional and immunologic milieu. Kidney transplant recipients (KTRs) are a unique and relevant population in which the function of adipocytokines can be examined, given their altered nutritional and immune status and subsequent dysregulation of adipocytokine metabolism. In this review, we summarize the recent findings about four specific adipocytokines and their respective roles in KTRs. We decided to evaluate the most widely described adipocytokines, including leptin, adiponectin, visfatin and resistin. Increasing evidence suggests that these adipocytokines may lead to cardiovascular events and metabolic changes in the general population and may also increase mortality and graft loss rate in KTRs. In addition, we present findings on the interrelationship between serum adipocytokine levels and nutritional and immunologic status, and mechanisms by which adipocytokines modulate morbidity and outcomes in KTRs.

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Resistin in inflammatory and degenerative rheumatologic diseases

Cited by 29 publications

References 37 publications

Adipokines as Potential Biomarkers in Rheumatoid Arthritis

Adipokines as Potential Biomarkers in Rheumatoid Arthritis

Adiponectin exacerbates collagen-induced arthritis via enhancing Th17 response and prompting RANKL expression

Adipocytokines in renal transplant recipients

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