Resistin gene polymorphism in offspring of patients with type 2 diabetes mellitus

Fawzy, Farid; Khalil, Osama A.; Salem, Hatem A.; Fawzy, Mohamed S

doi:10.1530/endoabs.41.gp82

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymorphism in resistin gene 299 (G>A) and increase in serum resistin is also known to be a contributing factor to increased insulin resistance with a subsequent higher risk of T2DM in offspring. Moreover, offspring carrying AA and combined GA + AA genotypes tend to be at higher risk [40]. On the other hand, diabetes also has the capacity to make genetic alterations leading to associated comorbidities.…”

Section: Adipose Tissue and Resistinmentioning

confidence: 99%

Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges, and Alternatives

et al. 2020

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) accounts for >90% of the cases of diabetes in adults. Resistance to insulin action is the major cause that leads to chronic hyperglycemia in diabetic patients. T2DM is the consequence of activation of multiple pathways and factors involved in insulin resistance and β-cell dysfunction. Also, the etiology of T2DM involves the complex interplay between genetics and environmental factors. This interplay can be governed efficiently by lifestyle modifications to achieve better management of diabetes. The present review aims at discussing the major factors involved in the development of T2DM that remain unfocussed during the anti-diabetic therapy. The review also focuses on lifestyle modifications that are warranted for the successful management of T2DM. In addition, it attempts to explain flaws in current strategies to combat diabetes. The employability of phytoconstituents as multitargeting molecules and their potential use as effective therapeutic adjuvants to first line hypoglycemic agents to prevent side effects caused by the synthetic drugs are also discussed.

show abstract

Section: Adipose Tissue and Resistinmentioning

confidence: 99%

Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges, and Alternatives

et al. 2020

View full text Add to dashboard Cite

show abstract

“…27,139 promoter region of RETN plays a critical role in resistin gene expression and determination of plasma resistin concentration in humans. 140 The most recent study performed by Fawzy et al 141 indicates that SNPs of RETN and increased serum resistin levels may be associated with increased IR and consequent susceptibility to T2D in offspringś of DM patients.…”

Section: Resistin and Type 2 Diabetes Mellitusmentioning

confidence: 99%

Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome

Borujeni

Esfandiary

Taheripak

et al. 2017

J of Cellular Biochemistry

View full text Add to dashboard Cite

Diabetes mellitus (DM) is known as one of important common endocrine disorders which could due to deregulation of a variety of cellular and molecular pathways. A large numbers studies indicated that various pathogenesis events including mutation, serin phosphorylation, and increasing/decreasing expression of many genes could contribute to initiation and progression of DM. Insulin resistance is one of important factors which could play critical roles in DM pathogenesis. It has been showed that insulin resistance via targeting a sequence of cellular and molecular pathways (eg, PI3 kinases, PPARγ co-activator-1, microRNAs, serine/threonine kinase Akt, and serin phosphorylation) could induce DM. Among of various factors involved in DM pathogenesis, microRNAs, and exosomes have been emerged as effective factors in initiation and progression of DM. A variety of studies indicated that deregulation of these molecules could change behavior of various types of cells and contribute to progression of DM. Resistin is other main factor which is known as signal molecule involved in insulin resistance. Multiple lines evidence indicated that resistin exerts its effects via affecting on glucose metabolism, inhibition of fatty acid uptake and metabolism with affecting on a variety of targets such as CD36, fatty acid transport protein 1, Acetyl-CoA carboxylase, and AMP-activated protein kinase. Here, we summarized various molecular aspects are associated with DM particularly the molecular pathways involved in insulin resistance and resistin in DM. Moreover, we highlighted exosomes and microRNAs as effective players in initiation and progression of DM.

show abstract

Prominent and emerging anti-diabetic molecular targets

Almasi

Mohammadipanah

2020

Journal of Drug Targeting

View full text Add to dashboard Cite

Resistin gene polymorphism in offspring of patients with type 2 diabetes mellitus

Cited by 3 publications

References 0 publications

Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges, and Alternatives

Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges, and Alternatives

Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome

Prominent and emerging anti-diabetic molecular targets

Contact Info

Product

Resources

About