Resistin expression and regulation in mouse pituitary

Morash, Barbara; Willkinson, Diane; Ur, Ehud; Wilkinson, Michael

doi:10.1016/s0014-5793(02)03108-3

Cited by 98 publications

(102 citation statements)

References 28 publications

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“…ERK1/2-MAPK phosphorylation was only affected in rat GCs. Protein and mRNA expression of resistin have been described in several tissues of the reproductive axis (Morash et al 2002, Nogueiras et al 2004, Brown et al 2005, Tovar et al 2005. Furthermore, resistin mRNA is expressed in the bovine mammary gland, and its expression in this tissue decreases during lactation (Komatsu et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, expression of resistin (mRNA and protein) has been reported in several reproductive tissues including hypothalamus (Morash et al 2002, Tovar et al 2005, pituitary (Morash et al 2002, Brown et al 2005, and testis (Nogueiras et al 2004). In hypothalamus, resistin has been shown to inhibit feeding (Tovar et al 2005, Vazquez et al 2008.…”

Section: Introductionmentioning

confidence: 99%

“…In pituitary, resistin expression is regulated in a nutritional-, age-, and gender-specific manner (Morash et al 2004). Resistin mRNA expression increases to a peak level in pituitary of pre-pubertal mice (Morash et al 2002(Morash et al , 2004. Furthermore, at this stage, pituitary mRNA resistin levels are strongly stimulated by corticosteroids (Brown et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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Expression and effect of resistin on bovine and rat granulosa cell steroidogenesis and proliferation

Maillard¹,

Froment²,

Ramé³

et al. 2011

Reproduction

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Resistin, initially identified in adipose tissue and macrophages, was implicated in insulin resistance. Recently, its mRNA was found in hypothalamo-pituitary axis and rat testis, leading us to hypothesize that resistin may be expressed in ovary. In this study, we determined in rats and cows 1) the characterization of resistin in ovary by RT-PCR, immunoblotting, and immunohistochemistry and 2) the effects of recombinant resistin (10, 100, 333, and 667 ng/ml)GIGF1 (76 ng/ml) on steroidogenesis, proliferation, and signaling pathways of granulosa cells (GC) measured by enzyme immunoassay, [3 H]thymidine incorporation, and immunoblotting respectively. We observed that resistin mRNA and protein were present in several bovine and rat ovarian cells. Nevertheless, only bovine GC abundantly expressed resistin mRNA and protein. Resistin treatment decreased basal but not IGF1-induced progesterone (P!0.05; whatever the dose) and estradiol (P!0.005; for 10 and 333 ng/ml) production by bovine GC. In rats, resistin (10 ng/ml) increased basal and IGF1-induced progesterone secretion (P!0.0001), without effect on estradiol release. We found no effect of resistin on rat GC proliferation. Conversely, in cows, resistin increased basal proliferation (P!0.0001; for 100-667 ng/ml) and decreased IGF1-induced proliferation of GC (P!0.0001; for 10-333 ng/ml) associated with a decrease in cyclin D2 protein level (P!0.0001). Finally, resistin stimulated AKT and p38-MAPK phosphorylation in both species, ERK1/2-MAPK phosphorylation in rats and had the opposite effect on the AMPK pathway (P!0.05). In conclusion, our results show that resistin is expressed in rat and bovine ovaries. Furthermore, it can modulate GC functions in basal state or in response to IGF1 in vitro.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression and effect of resistin on bovine and rat granulosa cell steroidogenesis and proliferation

Maillard¹,

Froment²,

Ramé³

et al. 2011

Reproduction

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“…In mice, resistin is almost exclusively expressed in white adipose tissue in proportion to adipocyte differentiation and the amount of adipose tissue [3]. It has also been found in the pituitary gland, the hypothalamus, and in the blood circulation [20]. Resistin in rats is secreted not only by adipose tissue, but has also been found in the gastrointestinal tract, adrenal glands, skeletal muscles, pancreas, and spleen [21,22,23].…”

Section: Sites Of Resistin Productionmentioning

confidence: 99%

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Filková

Haluzı́k

Šenolt

2009

Clinical Immunology

373

297

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“…58 Resistin is a 12.5 kDa cysteine-rich, C-terminal protein, whose mRNA expression has been predominantly observed in white adipose tissue, and to a lesser extent in the hypothalamus, the pituitary, BAT, the stomach, the large intestine, the adrenal gland and skeletal muscles, in rats. [59][60][61] In vitro studies showed that resistin is induced during adipocyte differentiation 53,57,62 and, as suggested by its signal sequence, is secreted into the media. 53 Mouse studies also showed that resistin is detectable in the serum, demonstrating that it can circulate in the blood.…”

Section: Resistinmentioning

confidence: 99%

Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance

2004

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Glucocorticoids are important hormones in the regulation of metabolic homeostasis. We infused normal rats with dexamethasone given intracerebroventricularly (i.c.v.) for 3 days. This resulted in hyperphagia, hyperinsulinemia, and marked insulin resistance. Similar metabolic defects were observed following i.c.v. infusion of neuropeptide Y (NPY) in normal rats. As central dexamethasone infusion enhanced NPY content in the arcuate nucleus, it suggested that its metabolic effects are mediated by NPY. Moreover, due to the lack of effects observed in vagotomized animals, activation of the parasympathetic nervous system by central dexamethasone infusion is proposed. Glucocorticoid action is known to involve prereceptor metabolism by enzymes such as 11b-HSD-1 that converts inactive into active glucocorticoids. Mice overexpressing 11b-HSD-1 in adipose tissue were shown to be obese and insulin resistant. We recently observed that adipose tissue 11b-HSD-1 mRNA expression is increased at the onset of high-fat diet-induced obesity and positively correlated with the degree of hyperglycemia. In human obesity, increased adipose tissue 11b-HSD-1 expression and activity were also reported. Resistin is a new adipose tissue-secreted hormone shown to play a role in glucose homeostasis by increasing hepatic glucose production and inhibiting muscle and adipose tissue glucose utilization. We observed increased adipose tissue resistin expression in the early phase of highfat diet-induced obesity as well as decreased resistin expression in response to leptin. A positive correlation between glycemia and adipose tissue resistin expression further suggested a role of this hormone in the development of insulin resistance. The melanocortin system is another important player in the regulation of energy balance. Peripheral administration of a melanocortin agonist decreased food intake and body weight and favored lipid oxidation, effects that were more marked in obese than in lean rats. It is proposed that both resistin and melanocortin agonists may influence adipose tissue 11b-HSD-1, thereby decreasing or enhancing glucose metabolism.

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Resistin expression and regulation in mouse pituitary

Cited by 98 publications

References 28 publications

Expression and effect of resistin on bovine and rat granulosa cell steroidogenesis and proliferation

Expression and effect of resistin on bovine and rat granulosa cell steroidogenesis and proliferation

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance

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