Resistin and visfatin in steatotic and non-steatotic livers in the setting of partial hepatectomy under ischemia-reperfusion

Use of Steatotic Grafts in Liver Transplantation: Current Status

“…Many of the previously mentioned studies (13 of 23) were performed in rat models with moderate steatotic livers. (53,57,62,63,65,66,76,(78)(79)(80)84,86,87) Of these studies,11 used fatty livers from Zucker rats (53,57,62,63,65,66,68,77,78,(87)(88)(89) ; 5 used a methionine-choline deficient diet (53,68,82,83,89) and 5 a HFD, (64,(79)(80)(81)85,88) both models of steatohepatitis. Finally, in 2 studies steatohepatitis was induced by alcohol.…”

“…Review ARticle | 779 Moreover, most of the reported studies have been performed in normothermic hepatic I/R models with or without hepatic resection (68,69,(82)(83)(84)(85)(86)(87)(88)(89) conditions that greatly differ from the clinical practice of LT. Additionally, mechanisms involved in hepatic IRI may differ depending on the method used to induce experimental steatosis. For example, as opposed to other models of steatosis, both dietary and alcohol exposure induce the production of SOD/catalase-insensitive ROS, which may partly explain steatotic failure after LT. Neutrophils, which have been implicated in the increased vulnerability of alcohol-induced steatotic livers to IRI, would not account for I/R damage in nonalcoholic steatotic livers.…”

Reduced delivery of epididymal adipocyte‐derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice

“…Resistin is an adipocytokine that has been identified to be strongly associated with obesity, local low‐grade inflammation, and metabolic syndrome . Recently, resistin has been regarded as a mark for liver injury and fibrosis in patients with NASH and related model mice . Moreover, increased level of circulating adiponectin and resistin is common characteristics both in cirrhosis patients and mice models, suggesting that altered pattern of adipocytokines may be involved in the modification of liver physiological conditions .…”

“…Excessive fat accumulation contributes to white adipose tissue (WAT) dysfunction which further alters the secretion pattern of multiple adipocytokines, including leptin, adiponectin, visfatin, and resistin. [14][15][16] Resistin is an adipocytokine that has been identified to be strongly associated with obesity, local low-grade inflammation, and metabolic syndrome. [17][18][19][20] Recently, resistin has been regarded as a mark for liver injury and fibrosis in patients with NASH and related model mice.…”

“…[17][18][19][20] Recently, resistin has been regarded as a mark for liver injury and fibrosis in patients with NASH and related model mice. 15,21 Moreover, increased level of circulating adiponectin and resistin is common characteristics both in cirrhosis patients and mice models, suggesting that altered pattern of adipocytokines may be involved in the modification of liver physiological conditions. 21 Since the high level of resistin is thought to trigger ER stress which is considered as an early stage and phenotype of hepatic steatosis, 22 adipocyte-derived exosomal resistin may act as a significant signaling molecule in regulatory pathways from adipose tissue to liver.…”