Resistin and Leptin Levels in Acromegaly: Lack of Correlation with Echocardiographic Findings

Gurbulak, Sabriye; Yaylalı, Güzin Fidan; Yerlikaya, Emrah; Akın, Fulya; Topsakal, Şenay; Tanrıverdi, Halil; Akdag, Beyza; Aslan, Ali

doi:10.2310/jim.0b013e3182823390

Journal of Investigative Medicine

2013

DOI: 10.2310/jim.0b013e3182823390

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Resistin and Leptin Levels in Acromegaly: Lack of Correlation with Echocardiographic Findings

Sabriye Gurbulak

Güzin Fidan Yaylalı

Emrah Yerlikaya

et al.

Abstract: We found biventricular hypertrophy and impairment of diastolic and systolic function in the patients with acromegaly. We conclude that changes in resistin and leptin levels are unlikely to account for the insulin resistance of acromegaly. They do not also seem to be contributing factors of cardiovascular changes in patients with acromegaly.

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Cited by 2 publications

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Acromegaly, inflammation and cardiovascular disease: a review

Wolters¹,

Netea

Riksen³

et al. 2020

Rev Endocr Metab Disord

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Acromegaly is characterized by Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) excess. Uncontrolled acromegaly is associated with a strongly increased risk of cardiovascular disease (CVD), and numerous cardiovascular risk factors remain present after remission. GH and IGF-1 have numerous effects on the immune and cardiovascular system. Since endothelial damage and systemic inflammation are strongly linked to the development of CVD, and have been suggested to be present in both controlled as uncontrolled acromegaly, they may explain the presence of both micro- and macrovascular dysfunction in these patients. In addition, these changes seem to be only partially reversible after remission, as illustrated by the often reported presence of endothelial dysfunction and microvascular damage in controlled acromegaly. Previous studies suggest that insulin resistance, oxidative stress, and endothelial dysfunction are involved in the development of CVD in acromegaly. Not surprisingly, these processes are associated with systemic inflammation and respond to GH/IGF-1 normalizing treatment.

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Acromegaly, inflammation and cardiovascular disease: a review

Wolters¹,

Netea

Riksen³

et al. 2020

Rev Endocr Metab Disord

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Serum visfatin levels in acromegaly: Correlation with disease activity and metabolic alterations

Ciresi

Amato

Pizzolanti

2015

Growth Hormone & IGF Research

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Objective: The studies that have extensively evaluated the relation between adipokines and metabolic parameters in acromegaly treatment are quite discordant. We aimed to evaluate and correlate a set of selected adipokines, known to have a metabolic role, with the disease activity, metabolic status and treatment modalities. ND patients showed higher VAI, triglycerides, Homa-IR, and visfatin and lower ISI Matsuda, M-value, and leptin compared to other groups (all p b 0.050), while no differences were found among SA, PE and SU patients. IGF-1 (p = 0.048), M-value (p = 0.0029) and VAI (p = 0.010) were independently associated with visfatin, while only ISI Matsuda (p = 0.019) was associated with leptin. Conclusions: In acromegaly visfatin could be considered a useful index of disease activity and metabolic alterations, such as insulin resistance and adipose dysfunction, regardless of the type of treatment.

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Resistin and Leptin Levels in Acromegaly: Lack of Correlation with Echocardiographic Findings

Cited by 2 publications

References 37 publications

Acromegaly, inflammation and cardiovascular disease: a review

Acromegaly, inflammation and cardiovascular disease: a review

Serum visfatin levels in acromegaly: Correlation with disease activity and metabolic alterations

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