Resistin adipokin in atopic dermatitis patients: A clinical, biochemical, and genetic study

Abstract

Background/Objectives Atopic dermatitis (AD) is an inflammatory chronic skin disorder. The etiology of AD is not fully understood. Therefore, we aimed by this study to shed light on the potential role of resistin in an etiopathogenesis of AD through investigation of resistin rs3745367 single nucleotide polymorphism (SNP) and resistin serum levels, and their relation to leukocytic count in a sample of Egyptian patients having atopic dermatitis. Methods This case‐control study included 45 patients having AD and 40 controls. SCORAD index was assessed to evaluate the severity of AD. CBC, ELISA, and PCR‐RFLP were performed to detect leukocytic count, resistin serum level, and resistin rs3745367 SNP, respectively. Results Atopic dermatitis patients had significant low serum resistin concentrations (P = .036) and a significantly high frequency of leukocytosis (P = .003). Low resistin serum levels were significantly related to AD disease severity (P < .001) and the presence of leukocytosis (P < .001). Resistin rs3745367 GG genotype (P = .030), as well as its G allele (P = .019), was expressively associated with AD development, and both increased the risk of AD by 3‐ and 2‐fold, respectively. Resistin rs3745367 GG genotype was significantly linked to low resistin serum levels (P < .001), AD‐positive family history (P = .015), and the presence of leukocytosis (P < .001). Conclusions Resistin rs3745367 gene polymorphism may contribute to the development of AD. Resistin may have an immune‐modulating active character in the AD etiopathogenesis that could be mediated through its anti‐inflammatory effect. From this piece of work, we may suggest resistin as a new therapy to mitigate the pro‐inflammatory environment found in AD.

Adipokines as Biomarkers of Atopic Dermatitis in Adults

“…Banihani et al [41] found a significant reduction in resistin in a group of 75 AD patients (children and adults) when compared to the control group. Likewise, Farag et al [42] have found a decrease in resistin in a group of 45 Egyptian patients (adults and children; obese patients excluded), with an inverse correlation between blood resistin content and SCORAD score, which was also found in the present study. Based on the available data, it is possible to hypothesize that consistently lower levels of resistin coexist with increased severity of AD symptoms in adults.…”

Associations between rs2241766 and rs3774261 polymorphisms in ADIPOQ gene and atopic dermatitis

“…Adiponectin signaling enhances sebum secretion and subsequent protection of the skin against AD (Jung et al, 2017). It has also been shown that levels of other adipokines such as resistin and leptin affect the risk of AD (Banihani et al, 2018;Farag et al, 2020;Jaworek & Szepietowski, 2020;Kovács et al, 2020;Seo & Seong, 2019). Thus, a considerable amount of literature supports the role of adipokines in AD disease.…”

Possible Role of Leptin in Atopic Dermatitis: A Literature Review

“…Adiponectin and resistin have been found to be inversely correlated to the intensity of eczema in adult patients compared with healthy subjects, thus being considered as promising biomarkers in the disease [ 68 , 69 ]. Specifically, the resistin rs3745367 gene polymorphism could contribute to the development of AD according to gender and age [ 69 , 70 ]. Surprisingly, Machura et al (2013) found higher levels of serum resistin in AD children (especially in boys) compared with healthy controls.…”