Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8

Wen, Fengyun; Xia, Qiao; Zhang, Hui; Shia, Haipeng; Amin, Rajesh; Wu, Yan-Ling; Yang, Yi; Zhou, Yang

doi:10.1155/2020/9767926

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…134 Resistin is found in elevated levels in obese patients, with high levels of the adipokine associated with a low-grade, chronic inflammation. 135,136 Similar to other proinflammatory adipokines, resistin promotes inflammation by activating NF-jB, 137 resulting in upregulation of IL-1b, IL-6, IL-16, and TNFa 132,138,139 after interacting with adenylyl cyclase-associated protein 1 (CAP1). 139 Similarly to leptin, resistin enhances STAT expression 140 and has the potential of activating PI3K 141 and MAPKs ERK and p38.…”

Section: Leptinmentioning

confidence: 99%

Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects

et al. 2021

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Hidradenitis suppurativa (HS) is a chronic, suppurative condition of the pilosebaceous unit.Patients suffering from HS demonstrate a molecular profile in keeping with a state of systemic inflammation and are often found to fit the criteria for a diagnosis of metabolic syndrome (MetS). In this paper, we review the literature with regards to established data on the prevalence of MetS in HS patients and revise the odds ratio of comorbid disease. Furthermore, we attempt to draw parallels between inflammatory pathways in HS and MetS and evaluate how convergences may explain the risk of comorbid disease, necessitating the need for multidisciplinary care.

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Section: Leptinmentioning

confidence: 99%

Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects

et al. 2021

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Resistin: A journey from metabolism to cancer

Deb

Deshmukh

Ramteke

et al. 2021

Translational Oncology

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β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting

Baghestani,

Haldin,

Kosijer

et al. 2024

American Journal of Physiology-Cell Physiology

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Islet β-cell dysfunction is an underlying factor for type I diabetes (T1D) development. Insulin sensing and secretion is tightly regulated in β-cells at multiple subcellular levels. The epithelial intermediate filament protein keratin (K) 8 is the main β-cell keratin, constituting the filament network with K18. To identify the cell-autonomous functions of K8 in β-cells, mice with targeted deletion of β-cell K8 (K8flox/flox; Ins-Cre) were analyzed for islet morphology, ultrastructure and integrity, as well as blood glucose regulation and streptozotocin (STZ)-induced diabetes development. Glucose transporter 2 (GLUT2) localization was studied in β-cells in vivo and in MIN6 cells with intact or disrupted K8/K18 filaments. Loss of β-cell K8 leads to a major reduction in K18. Islets without β-cell K8 are more fragile and these β-cells display disjointed plasma membrane organization with less membranous E-cadherin and smaller mitochondria, with diffuse cristae. Lack of β-cell K8 also leads to a reduced glucose stimulated insulin secretion response in vivo, despite undisturbed systemic blood glucose regulation. K8flox/flox; Ins-Cre mice have a decreased sensitivity to STZ compared to K8 wild-type mice, which is in line with decreased membranous GLUT2 expression observed in vivo, as GLUT2 is required for STZ uptake in β-cells. In vitro, MIN6 cell plasma membrane GLUT2 is rescued in cells overexpressing K8/K18 filaments, but mistargeted in cells with disrupted K8/K18 filaments. β-cell K8 is required for islet and β-cell structural integrity, normal mitochondrial morphology and GLUT2 plasma membrane targeting, and has implications on STZ sensitivity as well as systemic insulin responses.

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Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8

Cited by 4 publications

References 31 publications

Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects

Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects

Resistin: A journey from metabolism to cancer

β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting

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