Resistência induzível à clindamicina entre isolados clínicos de Staphylococcus aureus

Phenotypic and molecular characterization of resistance to macrolides, lincosamides and type B streptogramin of clinical isolates of Staphylococcus spp. of a university hospital in Recife, Pernambuco, Brazil

“…In this study, the 39 (37.9%) cMLS B phenotype isolates prevailed over the five (4.9%) iMLS B phenotype and over the 12 (11.6%) MS B phenotype resistant to macrolides and type B streptogramins, which is consistent with other studies conducted in Brazil. 12 , 13 , 22 One of the studies was performed in São Paulo revealed 37 (25.17%) and nine (6.12%) isolates with cMLS B and iMLS B phenotypes, respectively, while the MS B was not detected. 12 Other studies were conducted in the state of Rio Grande do Sul; one of them identified 71 (46.7%), five (3.3%), and five (3.3%) isolates with cMLS B , iMLS B , and MS B phenotypes, respectively.…”

“… 12 , 13 , 22 One of the studies was performed in São Paulo revealed 37 (25.17%) and nine (6.12%) isolates with cMLS B and iMLS B phenotypes, respectively, while the MS B was not detected. 12 Other studies were conducted in the state of Rio Grande do Sul; one of them identified 71 (46.7%), five (3.3%), and five (3.3%) isolates with cMLS B , iMLS B , and MS B phenotypes, respectively. 13 The other study detected 25 (17.9%), 11 (7.9%), and two (1.4%) isolates with cMLS B , iMLS B , and MS B phenotypes, respectively.…”

“…In this study the cMLS B phenotype prevailed among the isolates resistant to methicillin, which is consistent with studies conducted in other countries 3 , 5 , 11 , 15 , 21 as well in Brazil. 12 , 22 …”

“…reported the cMLS B phenotype as the most frequent. 12 , 13 Coutinho et al 13 have also evaluated the occurrence of the erm genes among the isolates analyzed. However, the frequency of cMLS B and iMLS B resistance varies among different hospitals and there are other resistance mechanisms that confer resistance to only one or two classes of the MLS B complex.…”

DETECÇÃO DE RESISTÊNCIA À METICILINA E AOS MACROLÍDEOS EM Staphylococcus aureus ISOLADOS DE JALECO

“…Os isolados resistentes a eritromicina e sensíveis à clindamicina foram submetidos ao D-teste para detectar resistência induzível a clindamicina. Estes foram semeados em ágar Mueller Hinton e um disco de eritromicina foi colocado a uma distância de 20 mm (borda a borda) do disco de clindamicina, e incubados a 35°C por 24 h. A eritromicina presente no disco difunde-se pelo meio de cultura e induz a resistência à clindamicina, resultando em um achatamento do halo de inibição, adjacente ao disco de eritromicina, com a forma da letra D (efeito D) 14 .…”