Resistencia inducible a clindamicina en Staphylococcus aureus meticilino resistente

Abstract

Clindamycin inducible resistance in methicillin-resistant Staphylococcus aureus Background: The increase in methicillin-resistant Staphylococcus aureus (MRSA) infections has limited the use of efective available antibiotics. Clindamycin, an alternative against MRSA, might have inducible resistance that is not detected by common antibiograms. The disk diffusion method (D-test) detects the inducible resistance. Objetive: To establish the frecuency of inducible resistance in MRSA from blood and secretion samples obtained from hospitalyzed patients. Methods: Prospective and descriptive research, including MRSA positive blood and secretion samples from patients of Hospital Luis Calvo Mackenna, between July 2005-July 2006. A D-test was performed to the samples. Results: 220 MRSA samples were obtained and D-test was performed on 155 of them. 80% of the samples came from tracheobronquial secretion and 90% had used antibiotics. From all analyzed MRSA isolates, 32 (20.6%) were Clindamycin susceptible and 14 (43.8%) had Clindamycin inducible resistance (D-test+). Conclusions: A high percentage of MRSA Clindamycin resistant was found. From MRSA Clindamycin susceptible, 43.8% had Clindamycin inducible resistance (D test+). D-test was implemented in the Microbiology Laboratory at Hospital Luis Calvo Mackenna, allowing the identification of MRSA isolates suceptible to Clindamicyn treatment.

Prevalence and Characterization of Antibiotic-Resistant Staphylococcus aureus Recovered from Pasteurized Cheese Commercialized in Panama City Markets

“…e results of the present study demonstrated that S. aureus isolates from pasteurized cheese in Panamanian markets were resistant to antibiotics from the macrolides class. ese results are in agreement with Montoya's [49], which showed S. aureus resistance to macrolides such as erythromycin and clindamycin from the lincosamide class. Multidrug resistance was observed in forty-two percent (42%) of the S. aureus isolates, including all the antibiotic classes used in the present study (Table 2), as reported by Rivera-Salazar et al [21].…”

Fenotipos de resistencia a meticilina, macrólidos y lincosamidas en Staphylococcus aureus aislados de un hospital de Valledupar, Colombia

“…La variable constitutiva (MLSBc) presenta un elevado nivel de resistencia a cualquier antimicrobiano del grupo MLSB; en este estudio se encontró una frecuencia superior a las referenciadas por otros autores y prevalencias muy inferiores a los reportados en otras investigaciones (18)(19)(20)(21)(22)(23)(24). Se encontró una frecuencia del 2 % de resistencia inducible a clindamicina (MLSBi), algunos autores presentan resultados similares a este estudio, mientras que otros trabajos difieren con porcentajes mayores para este fenotipo de resistencia (4,18,19,22,(24)(25)(26)(27).…”

Colonización y factores de virulencia de Staphylococcus aureus resistente a meticilina en una población infantil de Montería

“…Como control se utilizó la cepa de S. aureus ATCC 25923. Se analizaron la presencia de resistencia inducible a clindamicina mediante la prueba del DTest (19), y la susceptibilidad a mupirocina (200 µg) (20,21) y tigeciclina (15 µg), siguiendo las recomendaciones del CLSI (Clinical Laboratory Standards Institute) 2013. Los aislamientos de S. aureus resistentes a meticilina se conservaron en caldo LB (Luria Bertani) con glicerol al 10% a -70 °C.…”